(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Chemical Properties

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: soluble

form 

A solid

pka

8.76±0.23(Predicted)

color 

White to off-white

(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Usage And Synthesis

Description

HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8; IC₅₀ = 27.2 nM). It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC₅₀s = ≥3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC₅₀s = 7.9, 7.2, and 7 μM, respectively).

Uses

(2E)-N-Hydroxy-3-(5-methoxy[1,1'':4'',1''''-terphenyl]-2-yl)-2-propenamide, is a HDAC8 inhibitor with an IC50 of 27.2 nM.

(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide(1417997-93-3)Related Product Information

• 3-Piperidinecarboxamide, N-methyl-N-(phenylmethyl)-1-[[4-(trifluoromethyl)phenyl]methyl]-, hydrochloride (1:1)
• N-benzyl-N-Methyl-1-(4-(trifluoroMethyl)benzyl)piperidine-3-carboxaMide