E3 ligase Ligand 5
E3 ligase Ligand 5 Basic information
- Product Name:
- E3 ligase Ligand 5
- Synonyms:
-
- E3 ligase Ligand 5
- PROTAC ERRα ligand 1
- 4-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy]-3-(trifluoromethyl)benzonitrile
- PROTAC ERRα ligand 1,inhibit,PROTAC ERRα ligand-1,Inhibitor,PROTAC ERRα ligand1,Estrogen Receptor/ERR
- Benzonitrile, 4-[4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]-2-methoxyphenoxy]-3-(trifluoromethyl)-
- PROTAC ERRa ligand 1
- PROTAC ERRα ligand 1, 10 mM in DMSO
- (Z)-4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile
- CAS:
- 1264754-13-3
- MF:
- C19H11F3N2O4S
- MW:
- 420.36
- Mol File:
- 1264754-13-3.mol
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E3 ligase Ligand 5 Chemical Properties
- Density
- 1.53±0.1 g/cm3(Predicted)
- pka
- 7.31±0.20(Predicted)
- form
- Solid
- color
- Light yellow to green yellow
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E3 ligase Ligand 5 Usage And Synthesis
Description
E3L-4133, also known as E3 ligase Ligand 5, is an E3 ligase Ligand that can be used in PROTAC (proteolysis targeting chimera) technology to engage an E3 ubiquitin ligase. PROTAC is a two-headed molecule capable of removing specific unwanted proteins.
Uses
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively[1].
target
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist.
IC 50
ERRα: 0.04 μM (IC50); ERRγ: 2.8 μM (IC50)
References
[1] Patch RJ, et al. Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents. J Med Chem. 2011 Feb 10;54(3):788-808. DOI:10.1021/jm101063h
E3 ligase Ligand 5Supplier
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