4-ANTIPYRINECARBOXALDEHYDE Chemical Properties

Melting point:

162-165 °C (lit.)

Boiling point:

334.8±52.0 °C(Predicted)

Density 

1.292±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

-1.39±0.60(Predicted)

form 

crystalline powder

color 

Off white

Cosmetics Ingredients Functions

HAIR DYEING

InChI

1S/C12H12N2O2/c1-9-11(8-15)12(16)14(13(9)2)10-6-4-3-5-7-10/h3-8H,1-2H3

InChIKey

QFYZFYDOEJZMDX-UHFFFAOYSA-N

SMILES

[H]C(=O)C1=C(C)N(C)N(c2ccccc2)C1=O

CAS DataBase Reference

950-81-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-36/37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2933199090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich

4-ANTIPYRINECARBOXALDEHYDE Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

4-Antipyrinecarboxaldehyde was used in the synthesis of a new crown ether-antipyrine schiffs base.

Uses

A derivative of the analgesic drug Antipyrene (A697500) with antiviral activity.

Definition

ChEBI: 4-Formyl-antipyrine is a member of pyrazoles and a ring assembly.

General Description

4-Antipyrinecarboxaldehyde undergoes condensation with 4′-aminobenzo-15-crown-5- to yield functionalized crown ether.

Synthesis

4-Antipyrinecarboxaldehyde is prepared as follows:
(1)Add antipyrine to the preparation tank, then add the dosed amount of sulfuric acid and water, formulate the acidic solution with the content of 34-36%, then nitrosation reaction with sodium nitrite solution in the nitrosation vat, the reaction solution is put into the reduction tank, add the reducing agent for the reduction reaction, and then transfer the reduction solution to the hydrolysis tank, add the hydrolysis of sulfuric acid, and then pass the ammonia to neutralize it, to make 4-amino antipyrine oil;
(2) Add 4-aminoantipyrine oil to the acylation tank with methyl formate or formic acid for acylation reaction, and then cooling down crystallization centrifugation to get 4-antipyrine formaldehyde crystals.

4-ANTIPYRINECARBOXALDEHYDE(950-81-2)Related Product Information

• Ferrous sulfate
• Glucosamine sulfate
• Antipyrine
• RARECHEM AL BF 0663
• ANTIPYRINECARBOXYLIC ACID
• RARECHEM AL BI 0663
• 4-ANTIPYRINECARBOXALDEHYDE
• 4-(2-CHLORO-ACETYL)-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE
• PHENAZ
• 4-Acetylantipyrine