Basic information Safety Supplier Related

2-Ethyl-5-phenylisoxazolium-3'-sulfonate

Basic information Safety Supplier Related

2-Ethyl-5-phenylisoxazolium-3'-sulfonate Basic information

Product Name:
2-Ethyl-5-phenylisoxazolium-3'-sulfonate
Synonyms:
  • NEPIS
  • N-ETHYL-5-PHENYLISOXAZOLIUM-3'-SULFONATE
  • WOODWARDS REAGENT K
  • WOODWARD'S REAGENT K
  • 2-ETHYL-5-PHENYLISOXAZOLIUM-3'-SULPHONEATE
  • Isoxazolium, 2-ethyl-5-(3-sulfophenyl)-, inner salt
  • NEPIS 2-ETHYL-5-PHENYLISOXAZOLIUM-3''-SULFONATE
  • 3-(2-ETHYL-5-ISOXAZOLIO)BENZENESULFONATE 99+%
CAS:
4156-16-5
MF:
C11H11NO4S
MW:
253.27
EINECS:
223-988-7
Product Categories:
  • Biochemistry
  • Condensation & Active Esterification
  • Coupling Reactions (Peptide Synthesis)
  • Peptide Synthesis
  • Synthetic Organic Chemistry
Mol File:
4156-16-5.mol
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2-Ethyl-5-phenylisoxazolium-3'-sulfonate Chemical Properties

Melting point:
216-219 °C (dec.)
Density 
1.3854 (rough estimate)
refractive index 
1.4790 (estimate)
storage temp. 
Store at RT.
Merck 
10050
BRN 
4149224
CAS DataBase Reference
4156-16-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3

MSDS

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2-Ethyl-5-phenylisoxazolium-3'-sulfonate Usage And Synthesis

Chemical Properties

white to off-white crystalline powder

Uses

Peptide-bond former.

Purification Methods

Crystallise the reagent from diethyl ether or ethyl acetate/pet ether. [Lamas et al. J Am Chem Soc 108 5543 1986.] It is best purified by dissolving in excess of aqueous N HCl and precipitating with Me2CO to give a white fluffy solid. [Woodward et al. Tetrahedron 22 Suppl 8 321 1966, Fieser & Fieser Reagents for Organic Synthesis 1 385, 2 198.]

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