Basic information Description References Safety Supplier Related

Isoxazole

Basic information Description References Safety Supplier Related

Isoxazole Basic information

Product Name:
Isoxazole
Synonyms:
  • ISOXAZOLE
  • 1-Oxa-2-azacyclopentadiene
  • Isooxazole
  • ISOXAZOLE 98+%
  • 1,2-Oxazole
  • Isoxazole,99%
  • Different oxazole
  • Isoxazole 99%
CAS:
288-14-2
MF:
C3H3NO
MW:
69.06
EINECS:
206-018-7
Product Categories:
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Heterocyclic Building Blocks
  • Isoxazoles
  • Building Blocks
  • Isoxazoles, Oxadiazoles, Oxazoles
  • pharmacetical
  • Boronic ester
  • Isoxazole
  • Organoborons
  • Thiophens
Mol File:
288-14-2.mol
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Isoxazole Chemical Properties

Melting point:
-67.1°C
Boiling point:
93-95 °C(lit.)
Density 
1.078 g/mL at 25 °C(lit.)
vapor density 
2.4 (vs air)
refractive index 
n20/D 1.427(lit.)
Flash point:
48 °F
storage temp. 
Store at RT.
solubility 
167g/l
pka
-2.0(at 25℃)
BRN 
103773
InChIKey
CTAPFRYPJLPFDF-UHFFFAOYSA-N
CAS DataBase Reference
288-14-2(CAS DataBase Reference)
NIST Chemistry Reference
Isoxazole(288-14-2)
EPA Substance Registry System
Isoxazole (288-14-2)
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Safety Information

Hazard Codes 
F,Xi
Risk Statements 
11
Safety Statements 
16-23/33-33-29-7/9
RIDADR 
UN 1993 3/PG 2
WGK Germany 
3
10
Hazard Note 
Highly Flammable
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29349990

MSDS

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Isoxazole Usage And Synthesis

Description

As an important class of heterocycles, isoxazole is a five membered heterocyclic compound with various pharmacological actions, which is found in some natural products, such as ibotenic acid. It is used in the formation of the basis for a number of drugs, such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV.
The isoxazole ring is an essential pharmacophore in modern drug discovery. Some beta-lactamase-resistant antibiotics contain an isoxazole group, including cloxacillin, dicloxacillin, flucloxacillin, and the isoxazole group is also found in some steroid drug such as danazol.

References

https://en.wikipedia.org/wiki/Isoxazole
http://www.ijpcbs.com/files/volume3-2-2013/15.pdf

Chemical Properties

Colorless liquid

Uses

Natural insecticide.

Definition

ChEBI: A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.

Hazard

Narcotic and psychomimetic effects.

IsoxazoleSupplier

Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. Gold
Tel
1867-8026865- ;
Email
sdfantai@163.com;sdfantai@163.com
Products Intro
Product Name:Isoxazole
CAS:288-14-2
Purity:99 Package:1000KG Remarks:1000KG
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro
Product Name:Isoxazole, 98.5%
CAS:288-14-2
Purity:98.5% Package:1G;25G;5G
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Email
sh@meryer.com
Products Intro
Product Name:Isoxazole
CAS:288-14-2
Purity:98% Package:5g;25g Remarks:AAA123895
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Email
3bsc@sina.com
Products Intro
Product Name:Isoxazole
CAS:288-14-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Alfa Aesar
Tel
400-610-6006; 021-67582000
Email
saleschina@alfa-asia.com
Products Intro
Product Name:Isoxazole, 99%
CAS:288-14-2
Package:5g Remarks:L01607