ISOXAZOLE-5-CARBOXYLIC ACID Chemical Properties

Melting point:

144-148 °C(lit.)

Boiling point:

211.74°C (rough estimate)

Density 

1.5808 (rough estimate)

refractive index 

1.4543 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Powder

pka

2.29±0.10(Predicted)

color 

Slightly yellow

Water Solubility 

Slightly soluble in water.

Sensitive 

Moisture Sensitive

InChIKey

MIIQJAUWHSUTIT-UHFFFAOYSA-N

CAS DataBase Reference

21169-71-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-25-24-36-26

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29349990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

ISOXAZOLE-5-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

slightly yellow powder

Uses

Reaction conditions were found to allow the exclusive formation of isoxazole-5-carboxylic acid derivatives by conjugate addition, in acidic medium, of hydroxylamine to β-alkoxyvinyl trichloromethyl ketone in synthesis and reactivity of isoxazoles. Isoxazole-5-carboxylic acid participates in the Synthesis and evaluation of acylguanidine FXa inhibitors. 1, 1, 1-trichloro-4-methoxy-3-penten-2-one postulated in the preparation of isoxazole-5-carboxylic acid from trichloroacetyl chloride, ethyl vinyl ether and hydroxylamine is developed in a fully saturated nitrogen atom theerefore there is no possibility of conjugation with 4- substituents.

General Description

Isoxazole-5-carboxylic acid can be obtained via dehydration of 5-trichloromethylisoxazole.

ISOXAZOLE-5-CARBOXYLIC ACID(21169-71-1)Related Product Information

• isoxazol-5-amine
• ISOXAZOL-3-YLMETHYL-METHYL-AMINE
• ISOXAZOLE-5-CARBONYL CHLORIDE
• C-ISOXAZOL-3-YL-METHYLAMINE
• METHYL ISOXAZOLE-5-CARBOXYLATE
• ISOXAZOLIDIN-3-ONE
• 4-Aminoisoxazole
• Methyl isonicotinate
• Ethyl isonicotinate
• 2-[[(3aS,4R,6S,6aR)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol
• Isoxazol-4-ylmethanamine oxalate
• ISOXAFLUTOLE
• ISOXAZOLO[5,4-B]PYRIDIN-3-YLAMINE
• 5-Isoxazolecarboxylicacid,ethylester(9CI)
• 1,2-oxazol-3-ylMethanaMine hydrochloride
• 3-AMINOISOXAZOLO[4,5-B]PYRAZINE
• Isoxazole-4-boronicacid
• C-ISOXAZOL-5-YL-METHYLAMINE HYDROCHLORIDE