Basic information Safety Supplier Related

ISOXAZOLE-5-CARBOXYLIC ACID

Basic information Safety Supplier Related

ISOXAZOLE-5-CARBOXYLIC ACID Basic information

Product Name:
ISOXAZOLE-5-CARBOXYLIC ACID
Synonyms:
  • TIMTEC-BB SBB004319
  • AKOS PAO-1371
  • ISOXAZOLE-5-CARBOXYLIC ACID
  • BUTTPARK 27\08-41
  • 5-Isoxazolecarboxylic acid
  • Isoxazole-5-carboxylic acid 98%
  • Isoxazole-5-carboxylic acid ,98%
  • 5-Carboxyisoxazole, 1,2-Oxazole-5-carboxylic acid, 5-Carboxy-1,2-oxazole
CAS:
21169-71-1
MF:
C4H3NO3
MW:
113.07
Product Categories:
  • carboxylic acid
  • Oxazole&Isoxazole
  • Building Blocks
  • Heterocyclic Building Blocks
  • Isoxazoles
Mol File:
21169-71-1.mol
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ISOXAZOLE-5-CARBOXYLIC ACID Chemical Properties

Melting point:
144-148 °C(lit.)
Boiling point:
211.74°C (rough estimate)
Density 
1.5808 (rough estimate)
refractive index 
1.4543 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Powder
pka
2.29±0.10(Predicted)
color 
Slightly yellow
Water Solubility 
Slightly soluble in water.
Sensitive 
Moisture Sensitive
InChIKey
MIIQJAUWHSUTIT-UHFFFAOYSA-N
CAS DataBase Reference
21169-71-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-25-24-36-26
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
IRRITANT
HS Code 
29349990

MSDS

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ISOXAZOLE-5-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

slightly yellow powder

Uses

Reaction conditions were found to allow the exclusive formation of isoxazole-5-carboxylic acid derivatives by conjugate addition, in acidic medium, of hydroxylamine to β-alkoxyvinyl trichloromethyl ketone in synthesis and reactivity of isoxazoles. Isoxazole-5-carboxylic acid participates in the Synthesis and evaluation of acylguanidine FXa inhibitors. 1, 1, 1-trichloro-4-methoxy-3-penten-2-one postulated in the preparation of isoxazole-5-carboxylic acid from trichloroacetyl chloride, ethyl vinyl ether and hydroxylamine is developed in a fully saturated nitrogen atom theerefore there is no possibility of conjugation with 4- substituents.

General Description

Isoxazole-5-carboxylic acid can be obtained via dehydration of 5-trichloromethylisoxazole.

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