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Trifluoroacetic anhydride

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Trifluoroacetic anhydride Basic information

Product Name:
Trifluoroacetic anhydride
Synonyms:
  • TIFLUOROACETIC ANHYDRIDE
  • TRIFLUOROACETO ANHYDRIDE
  • Trifluoroacetic acid anhydride (TFAH)
  • RIFLUOROACETIC ANHYDRIDE
  • Trifluoroacetic anhydride 10g [407-25-0]
  • Trifluoroacetic anhy
  • Trifluoroacetic anhydride, min. 98%
  • trifluoroacetyl 2,2,2-trifluoroacetate
CAS:
407-25-0
MF:
C4F6O3
MW:
210.03
EINECS:
206-982-9
Product Categories:
  • Pharmaceutical intermediates
  • Acylation Reagent
  • Halogen compounds
  • Organic Fluorides
  • Building Blocks
  • top
  • Acylation (GC Derivatizing Reagents)
  • Analytical Chemistry
  • Fluorinated Building Blocks
  • organofluorine compound
  • Carbonyl Compounds
  • Carboxylic Acid Anhydrides
  • Chemical Synthesis
  • Organic Building Blocks
  • Organics
  • Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds
  • GC Derivatizing Reagents
  • Synthetic Organic Chemistry
  • 407-25-0
Mol File:
407-25-0.mol
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Trifluoroacetic anhydride Chemical Properties

Melting point:
-65 °C (lit.)
Boiling point:
39.5-40 °C (lit.)
Density 
1.511 g/mL at 20 °C (lit.)
vapor pressure 
6.28 psi ( 20 °C)
refractive index 
n20/D 1.3(lit.)
Flash point:
-26 °C
storage temp. 
2-8°C
solubility 
Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
form 
Liquid
color 
Clear
Specific Gravity
1.487
Water Solubility 
Hydrolysis
Sensitive 
Moisture Sensitive
BRN 
746197
Stability:
Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
CAS DataBase Reference
407-25-0(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry System
Acetic acid, trifluoro-, anhydride (407-25-0)
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Safety Information

Hazard Codes 
C,T
Risk Statements 
14-20-35-52/53-34-23/24/25
Safety Statements 
26-36/37/39-43-45-61-9-8-28A-27
RIDADR 
UN 3265 8/PG 1
WGK Germany 
2
RTECS 
AJ9800000
3-10
Hazard Note 
Corrosive/Moisture Sensitive
TSCA 
T
HazardClass 
8
PackingGroup 
I
HS Code 
29159080
Toxicity
skn-rbt 500 mg/24H SEV 28ZPAK -,91,72

MSDS

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Trifluoroacetic anhydride Usage And Synthesis

Chemical Properties

Clear, colorless liquid

Uses

Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.

Uses

Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

Safety Profile

A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit

Purification Methods

Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

Trifluoroacetic anhydride Preparation Products And Raw materials

Preparation Products

Chlorfenapyr2-Chloro-4-(trifluoromethyl)pyrimidine2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamineEthyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLEEthyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINEETHYL 5-AMINO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE2-Hydroxymethyl-5-bromopyridine3-Nitroisonicotinic acidEthyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate5-Bromopyridine-2-carbaldehydeN10-(TRIFLUOROACETYL)PTEROIC ACIDtert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97%2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINIC ACID(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide3-CHLORO-5-NITROPYRIDINE2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine2,6-DICHLORO-4-ISOCYANATOPYRIDINE2-Hydroxy-4-(trifluoromethyl)pyrimidine2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acidEthyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate2-(Bromomethyl)-6-methylpyridine2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE6-Aminobenzothiazole5-Iodo-2,4-dimethoxypyrimidine2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE2-(TRIFLUOROACETYL)THIOPHENE[Bis(trifluoroacetoxy)iodo]benzene3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride2-CYANO-4-PYRIDINE CARBOXYLIC ACID3-(Trifluoromethyl)pyrazole

Raw materials

Trifluoroacetic anhydrideSupplier

Jinan Wanxingda Chemical Co., Ltd. Gold
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Adamas Reagent, Ltd. Gold
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Ji'nan Langhua Chemical Co. Ltd. Gold
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