Trifluoroacetamide Chemical Properties

Melting point:

65-70 °C (lit.)

Boiling point:

162.5 °C (lit.)

Density 

1.4176 (estimate)

Flash point:

162-164°C

storage temp. 

Store below +30°C.

solubility 

460 g/L (20°C)

pka

12.33±0.50(Predicted)

form 

Crystalline Powder or Crystals

color 

White to pale yellow or beige

PH

3.6 (460g/l, H2O, 23℃)

Water Solubility 

460 g/L (20 ºC)

BRN 

1753625

InChIKey

NRKYWOKHZRQRJR-UHFFFAOYSA-N

LogP

0.725 at 23℃ and pH4.83

Dissociation constant

0 at 23℃

CAS DataBase Reference

354-38-1(CAS DataBase Reference)

NIST Chemistry Reference

Acetamide, 2,2,2-trifluoro-(354-38-1)

EPA Substance Registry System

Acetamide, 2,2,2-trifluoro- (354-38-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

RIDADR 

1759

WGK Germany 

3

Hazard Note 

Harmful/Irritant

TSCA 

T

HazardClass 

8

PackingGroup 

III

HS Code 

29241900

MSDS

• Language:English Provider:2,2,2-Trifluoroacetamide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Trifluoroacetamide Usage And Synthesis

Chemical Properties

white to pale yellow or beige crystalline powder

Uses

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

Application

Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies.

Preparation

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292

General Description

Trifluoroacetamide is a good quencher of tryptophan fluorescence.

Trifluoroacetamide(354-38-1)Related Product Information

• N-6-Trifluoroacetyl-L-lysine
• Trifluoroacetamidine
• Methyl trifluoroacetate
• Potassium trifluoroacetate
• AMMONIUM TRIFLUOROACETATE
• THALLIUM(III) TRIFLUOROACETATE
• Silver trifluoroacetate
• Trifluoroacetophenone
• Trifluoroacetic acid
• Trifluoroacetic anhydride
• 3-TRIMETHYLSILYL-2-PROPYN-1-OL
• SULFUR TRIOXIDE TRIMETHYLAMINE COMPLEX
• Boron trifluoride tetrahydrofuran complex
• 2,2,2-Trifluoroethylamine hydrochloride
• Trifluoroacetonitrile
• 2,2,2-TRIFLUOROETHYLAMINE
• Methanesulfonic acid, 1,1,1-trifluoro-, 5-hydroxy-1-naphthalenyl ester
• Bis(trimethylsilyl)trifluoroacetamide