3-TRIMETHYLSILYL-2-PROPYN-1-OL Chemical Properties

Melting point:

63.5-65.0 °C

Boiling point:

76 °C11 mm Hg(lit.)

Density 

0.865 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.451(lit.)

Flash point:

152 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Benzene (Sparingly)

pka

13.71±0.10(Predicted)

form 

Liquid

color 

Clear yellow

Specific Gravity

0.865

Water Solubility 

Not miscible with water.

Sensitive 

Moisture Sensitive

Hydrolytic Sensitivity

4: no reaction with water under neutral conditions

BRN 

1902505

InChIKey

ZVGCJDPEKKEYES-UHFFFAOYSA-N

CAS DataBase Reference

5272-36-6(CAS DataBase Reference)

NIST Chemistry Reference

3-Trimethylsilylpropargyl alcohol(5272-36-6)

EPA Substance Registry System

2-Propyn-1-ol, 3-(trimethylsilyl)- (5272-36-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25-37/39-26

RIDADR 

2810

WGK Germany 

3

F 

8-10

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29319090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-TRIMETHYLSILYL-2-PROPYN-1-OL Usage And Synthesis

Chemical Properties

clear yellow liquid

Uses

Trimethylsilylpropargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.

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