2,2,2-Trifluoroethylamine hydrochloride Chemical Properties

Melting point:

220-222 °C (subl.)(lit.)

Density 

1,24g/cm

refractive index 

1,3-1,302

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

color 

White to Light yellow to Light orange

Water Solubility 

It is Soluble in 0.7 to water, but soluble in ethanol and chloroform, slightly soluble in benzene, hardly soluble in ether.

Sensitive 

Hygroscopic

BRN 

3652103

InChI

InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H

InChIKey

ZTUJDPKOHPKRMO-UHFFFAOYSA-N

SMILES

C(F)(F)(F)CN.Cl

CAS DataBase Reference

373-88-6(CAS DataBase Reference)

EPA Substance Registry System

Ethanamine, 2,2,2-trifluoro-, hydrochloride (373-88-6)

Safety Information

Hazard Codes 

Xn,T,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

36/37-24/25-36-26

WGK Germany 

3

RTECS 

KS0250000

F 

3-10-21

Hazard Note 

Hygroscopic/Toxic

TSCA 

T

HazardClass 

IRRITANT

PackingGroup 

III

HS Code 

29211990

Toxicity

LD50 unr-mus: 476 mg/kg 11FYAN 3,81,63

MSDS

• Language:English Provider:2,2,2-Trifluoroethylamine hydrochloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,2,2-Trifluoroethylamine hydrochloride Usage And Synthesis

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE POWDER

Uses

2,2,2-Trifluoroethylamine Hydrochloride is a reagent in the synthesis of arachidonylethanolamide analogs. These show affinity for CB1 and CB2 cannabinoid receptors.

Safety Profile

Moderately toxic by unspecifiedroute. When heated to decomposition it emits very toxicfumes of F??, NOx, and HCl.

Synthesis

General procedure for the synthesis of 2,2,2-trifluoroethylamine hydrochloride from 2,2,2-trifluoroethylamine: 100 g of ethanol and 33 g of 2,2,2-trifluoroethylamine were added to a triple-necked flask, and 35 g of saturated hydrochloric acid solution was added slowly and dropwise at temperatures lower than 25°C. The reaction system was then brought up to 50°C and maintained there for 1 hour. After the dropwise addition, the temperature of the reaction system was raised to 50 °C and maintained for 1 hour. Subsequently, the temperature of the reaction solution was controlled to be 45±5°C under a vacuum of 0.98 MPa and a decompression distillation was carried out for 5 hours to remove water and ethanol. Finally 43.5 g of 2,2,2-trifluoroethylamine hydrochloride was obtained in 96.30% yield. The resulting product was a white powdery crystalline solid with 0.13% water.

References

[1] Patent: CN105801428, 2016, A. Location in patent: Paragraph 0016; 0017

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