2-Phenylethylamine hydrochloride Chemical Properties

Melting point:

220-222 °C(lit.)

Boiling point:

217 °C

Flash point:

81 °C

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 10 mg/ml

form 

Powder or Crystalline Powder

color 

White to off-white

Merck 

14,6026

BRN 

3624163

InChI

InChI=1S/C8H11N.ClH/c9-7-6-8-4-2-1-3-5-8;/h1-5H,6-7,9H2;1H

InChIKey

SKHIBNDAFWIOPB-UHFFFAOYSA-N

SMILES

C1(CCN)=CC=CC=C1.Cl

LogP

1.458 (est)

CAS DataBase Reference

156-28-5(CAS DataBase Reference)

NIST Chemistry Reference

2-Phenylethylammonium chloride(156-28-5)

EPA Substance Registry System

Benzeneethanamine, hydrochloride (156-28-5)

Safety Information

Hazard Codes 

Xn,Xi,C

Risk Statements 

22-36/37/38-34

Safety Statements 

26-36-45-36/37/39

RIDADR 

2811

WGK Germany 

3

RTECS 

SH7175000

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

eye-man 50 mg SEV AIMDAP 39,404,27

MSDS

• Language:English Provider:SigmaAldrich

2-Phenylethylamine hydrochloride Usage And Synthesis

Description

2-Phenethylamine is a natural monoamine alkaloid that acts as neuromodulator in the central nervous system. It stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases as well as other enzymes. This product is intended for forensic and research applications.

Chemical Properties

White to Light yellow powder to crystal. soluble in water, alcohol, ether.

Uses

2-Phenylethylamine hydrochloride is the hydrochloride salt form of 2-Phenylethylamine, which is an biogenic aromatic amine acting as a monoaminergic neuromodulator or a neurotransmitter in the human central nervous system. It is used to CNS stimulant.

Preparation

In a nitrogen environment, add the aliphatic nitro derivatives (0.6 mmol), pinacol borane (3.6 mmol, 6.0 equiv), tetrahydrofuran (2 mL), triethylboron (5 mol%), and potassium tert-butoxide (5 mol %) into a 10 mL sealed tube and then place it in a 100 oil bath with heating and stirring for 24 hours. At the end of the reaction, add 2mL of 1M hydrochloric acid aqueous solution to the reaction solution and stir at room temperature for 6 h. Finally, 2-Phenylethylamine hydrochloride is obtained by filtration.

Safety Profile

Poison by skin contact, subcutaneous, and intravenous routes. A human eye irritant. A skin irritant and possible sensitizer. Human systemic effects by ingestion: blood pressure lowering, anorexia. When heated to decomposition it emits very toxic fumes of

References

[1] MASATO NAKAMURA  Daiichiro N  Akira Ishii. Characterization of β-phenylethylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study[J]. European journal of pharmacology, 1998, 349 2: Pages 163-169. DOI: 10.1016/s0014-2999(98)00191-5
[2] H Y YANG  N H N. Beta-phenylethylamine: a specific substrate for type B monoamine oxidase of brain.[J]. Journal of Pharmacology and Experimental Therapeutics, 1973, 187 2: 365-371.
[3] O. SUZUKI  M. O  Y Katsumata. Oxidation of β-Phenylethylamine by Both Types of Monoamine Oxidase: Examination of Enzymes in Brain and Liver Mitochondria of Eight Species[J]. Journal of Neurochemistry, 1981, 36 3: 1298-1301. DOI: 10.1111/j.1471-4159.1981.tb01734.x

2-Phenylethylamine hydrochloride(156-28-5)Related Product Information

• Ethylamine hydrochloride
• Ammonium chloride
• Sodium chloride
• Thionyl chloride
• D-Glucosamine hydrochloride
• Cysteamine hydrochloride
• L-1-Phenylethylamine
• Polyvinyl chloride
• Pivaloyl chloride
• Triethylamine hydrochloride
• Methoxyammonium chloride
• 2-Chloroethylamine hydrochloride
• Topotecan hydrochloride
• Calcium chloride
• Choline chloride
• Potassium chloride
• 2-PhenylethylaMine
• tranylcypromine