Potassium trifluoroacetate Chemical Properties

Melting point:

140-142 °C (lit.)

Density 

1.49 g/mL (lit.)

vapor pressure 

0Pa at 25℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

H₂O: 0.1 g/mL, clear, colorless

form 

solid

Specific Gravity

1.49

color 

White to Pale Yellow

Water Solubility 

Soluble in water.

Hydrolytic Sensitivity

0: forms stable aqueous solutions

Sensitive 

Hygroscopic

BRN 

3717603

Stability:

Very Hygroscopic

InChIKey

CUNPJFGIODEJLQ-UHFFFAOYSA-M

LogP

-3.12 at 20℃

CAS DataBase Reference

2923-16-2(CAS DataBase Reference)

EPA Substance Registry System

Acetic acid, 2,2,2-trifluoro-, potassium salt (1:1) (2923-16-2)

Safety Information

Hazard Codes 

Xi,N,T+

Risk Statements 

36/37/38-50-28

Safety Statements 

26-36-61-45-22-20-37

RIDADR 

3288

WGK Germany 

3

F 

3-10

Hazard Note 

Irritant/Hygroscopic

TSCA 

No

HazardClass 

IRRITANT, MOISTURE SENSITIVE, HYGROSCOPIC

HazardClass 

6.1

PackingGroup 

II

HS Code 

29159000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Potassium trifluoroacetate Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

It is a reagent for preparation of aryl trifluoromethyl sulfides, by heating with the diaryl disulfide.

Flammability and Explosibility

Non flammable

Synthesis

Example 14: Synthesis of potassium trifluoroacetate (CF3-COOK(5)); In a 500 mL glass flask, 20 mL of water, 73 mL of acetonitrile (MeCN), 1.33 g of potassium bromide (KBr), 0.46 g of TEMPO, and 10 g of 2,2,2-trifluoroethanol were sequentially added. The flask was equipped with a dropping funnel and a stirrer. An aqueous solution of sodium hypochlorite (NaOCl) (15 wt%, 175 mL) with pH adjusted to 8-9 was added in three batches through the dropping funnel under stirring at room temperature and the addition process took two days. Upon completion of the reaction, concentrated sulfuric acid and water were added to the reaction mixture to adjust the pH to 1-2. The reaction mixture was extracted three times with ether. The ether phases were combined and dried with magnesium sulfate, followed by distillation at atmospheric pressure to remove the ether. To the distillate was added 60 mL of methanol and 7 g of potassium methanolate and stirred for 1 h at room temperature. The solvent was evaporated after filtration to give potassium trifluoroacetate (13.13 g, 86% yield) as a colorless solid.19F NMR (D2O): -76.82 (s, 3F).

Purification Methods

To purify it, dissolve the salt in trifluoroacetic acid with ca 2% of trifluoroacetic anhydride, filter it and evaporate it carefully to dryness (avoid over heating), and finally dry it in a vacuum at 100o. It can be recrystallised from trifluoroacetic acid (solubility in the acid is ca 50.1%). [Simons & Lorentzen J Am Chem Soc 74 4746 1952, Hara & Cady J Am Chem Soc 76 4285 1954, Watt & Muga J Inorg Nucl Chem 9 166 1959, Beilstein 2 IV 458.]

References

[1] Patent: WO2011/50131, 2011, A2. Location in patent: Page/Page column 40
[2] Journal of Fluorine Chemistry, 2012, vol. 141, p. 35 - 40

Potassium trifluoroacetate(2923-16-2)Related Product Information

• Potassium sulfate
• Sodium trifluoroacetate
• Silver trifluoroacetate
• Trifluoroacetic acid
• Trifluoroacetic anhydride
• Losartan potassium
• Ethyl trifluoroacetate
• Potassium persulfate
• Potassium sorbate
• Potassium Acetate
• Potassium iodide
• Methyl trifluoroacetate
• Ethyl 4,4,4-trifluoroacetoacetate
• THALLIUM(III) TRIFLUOROACETATE
• Potassium chloride
• Trifluoroacetamide
• N-6-Trifluoroacetyl-L-lysine
• AMMONIUM TRIFLUOROACETATE