Methyl trifluoroacetate Chemical Properties

Melting point:

-78 °C

Boiling point:

43-43.5 °C (lit.)

Density 

1.273 g/mL at 25 °C (lit.)

vapor pressure 

5.77 psi ( 20 °C)

refractive index 

n20/D 1.291(lit.)

Flash point:

19 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

8g/l

form 

Liquid

Specific Gravity

1.273

color 

Clear colorless

PH

7 (8g/l, H2O, 20℃)

explosive limit

6.1-24.8%(V)

Water Solubility 

8 g/L

Sensitive 

Moisture Sensitive

BRN 

1756070

Dielectric constant

11.460000000000001

Stability:

Volatile

LogP

0.6

CAS DataBase Reference

431-47-0(CAS DataBase Reference)

NIST Chemistry Reference

CF3C(O)OCH3(431-47-0)

EPA Substance Registry System

Acetic acid, trifluoro-, methyl ester (431-47-0)

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-34

Safety Statements 

16-26-36/37/39-45

RIDADR 

UN 2924 3/PG 2

WGK Germany 

1

F 

19

Hazard Note 

Flammable/Corrosive

TSCA 

T

HazardClass 

3

PackingGroup 

II

HS Code 

29159080

MSDS

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Methyl trifluoroacetate Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Methyl trifluoroacetate has been used as reagent for trifluoroacetylation of amines and amino acids.

Synthesis Reference(s)

Journal of the American Chemical Society, 113, p. 700, 1991 DOI: 10.1021/ja00002a063

General Description

Methyl trifluoroacetate along with cesium fluoride or cesium chloride and CuI constitutes a valuable trifluoromethylating reagent for substituting aromatic (or heteroaromatic) iodides and bromides. Adsorption of methyl trifluoroacetate on amorphous silica has been investigated. Fragmentation mechanism of generation of metastable ions from methyl trifluoroacetate has been investigated by mass analyzed ion kinetic energy spectra and ab initio molecular orbital calculations.

Flammability and Explosibility

Flammable

Methyl trifluoroacetate(431-47-0)Related Product Information

• Methylparaben
• Methyl acetate
• Trifluoroacetic anhydride
• METHYL DIFLUOROACETATE
• Trifluoroacetic acid
• Methyl acrylate
• Bensulfuron methyl
• Thiophanate-methyl
• Ethyl trifluoroacetate
• Kresoxim-methyl
• PHENYL TRIFLUOROACETATE
• Ethyl 4,4,4-trifluoroacetoacetate
• Potassium trifluoroacetate
• Tetramethylammonium trifluoromethanethiolate
• TRIFLUOROMETHANESULFONIC ACID TRIFLUOROMETHYL ESTER
• Methyl
• PENTAFLUOROPHENYL TRIFLUOROACETATE
• Trifluoroacetamide