Ethyl trifluoroacetate Chemical Properties

Melting point:

-78 °C

Boiling point:

60-62 °C(lit.)

Density 

1.194 g/mL at 25 °C(lit.)

vapor pressure 

18.5kPa at 20℃

refractive index 

n20/D 1.307(lit.)

Flash point:

30 °F

storage temp. 

2-8°C

solubility 

4g/l

form 

Liquid

pka

0.43[at 20 ℃]

Specific Gravity

1.194

color 

Clear

PH

4 (4g/l, H2O, 20℃)

Water Solubility 

HYDROLYSIS

Sensitive 

Moisture Sensitive

BRN 

1761411

Stability:

Hygroscopic, Moisture Sensitive, Volatile

InChIKey

STSCVKRWJPWALQ-UHFFFAOYSA-N

LogP

0.79-1.032 at 25℃

CAS DataBase Reference

383-63-1(CAS DataBase Reference)

NIST Chemistry Reference

Acetic acid, trifluoro-, ethyl ester(383-63-1)

EPA Substance Registry System

Ethyl trifluoroacetate (383-63-1)

Safety Information

Hazard Codes 

F,Xn,C

Risk Statements 

11-22-37/38-41-34

Safety Statements 

9-16-26-36/39-45-36/37/39

RIDADR 

UN 1993 3/PG 2

WGK Germany 

1

Hazard Note 

Flammable/Corrosive

TSCA 

T

HazardClass 

3

PackingGroup 

II

HS Code 

29159080

MSDS

• Language:English Provider:Ethyl trifluoroacetate
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Ethyl trifluoroacetate Usage And Synthesis

Chemical Properties

Colorless to yellow liquid

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

Uses

Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.

Uses

Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of tri fluoroacylated compounds.

Preparation

Trifluoroacetic acid and ethanol were used as starting materials with strong-acid cation exchange resin as catalysts at 40 ~ 50 she℃. Add ethanol drop and temperature rising reflux divides the mixture of water and ethanol. After that, collect the mix of thick product ethanol and Ethyl trifluoroacetate. The crude product collected is added a small amount of water, and layering can obtain a content of more than 99.5%. The qualified product Ethyl trifluoroacetate, whose moisture is less than 0.1%, yields more than 95%.

Definition

ChEBI: TRIFLUOROACETIC ACID ETHYL ESTER is an organohalogen compound. It is functionally related to a carboxylic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 3527, 1950 DOI: 10.1021/ja01164a056

Flammability and Explosibility

Highly flammable

Purification Methods

Fractionate it through a long Vigreux column (p 11). IR has max at 1800 (CO2) and 1000 (OCO) cm-1 [Fuson et al. J Chem Phys 20 1627 1952, Bergman J Org Chem 23 476 1958]. [Beilstein 2 IV 463.]

Ethyl trifluoroacetate(383-63-1)Related Product Information

• Ethyl fluoroacetate
• Trifluoroacetic anhydride
• Ethyl cellulose
• Ethylbenzene
• Trifluoroacetic acid
• CHLOROETHANE
• Ethylparaben
• ETHYL CHLOROFLUOROACETATE
• Ethanol
• Ethyl acetate
• Ethyl difluoroacetate
• 2,2,2-Trifluoroethyl acrylate
• Ethyl acrylate
• Ethyl formate
• 2,4,6-TRIMETHOXY-1,3,5-TRIAZINE
• TRICAPRIN
• Triethylene glycol diacetate
• TRIMETHYLSILYL ISOCYANATE