Trimethylsilyl Isocyanate Chemical Properties

Melting point:

-49°C

Boiling point:

90-92 °C(lit.)

Density 

0.851 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.396(lit.)

Flash point:

-2 °C

storage temp. 

2-8°C

solubility 

Miscible with ethers and o-dichlorobenzene.

form 

clear liquid

color 

Colorless to Almost colorless

Specific Gravity

0.867

Hydrolytic Sensitivity

8: reacts rapidly with moisture, water, protic solvents

Sensitive 

Moisture Sensitive

BRN 

1744962

CAS DataBase Reference

1118-02-1(CAS DataBase Reference)

EPA Substance Registry System

Isocyanatotrimethylsilane (1118-02-1)

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23-36/37-42

Safety Statements 

23-26-36/37/39-45

RIDADR 

UN 2478 3/PG 2

WGK Germany 

3

F 

10-19-21

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29319090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Trimethylsilyl Isocyanate Usage And Synthesis

Chemical Properties

Clear colorless liquid

Uses

Trimethylsilyl isocyanate is used in the preparation of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones. It finds application in the carbamoylation of aromatic hydrocarbons and alcohols. It is also used in the preparation of primary amides from Grignard reagents. Further, it is used in the synthesis of cyclic imides. It is also utilized for the synthesis of trifluoroacetyl isocyanate and cyclic imides. In addition to this, it is employed in the conversion of isocyanates to carbodiimides using cyclopentadienyl Mn(CO)3 catalysis.

Application

Trimethylsilyl Isocyanate was used in:
postsynthetic modification of isoreticular metal-organic framework-3;
synthesis of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones;
conversion of isocyanates to carbodiimides with cyclopentadienyl Fe(CO)2 or -Mn(CO)3 catalysis;
carbamoylation of aromatic hydrocarbons and alcohols

Materials Uses

Calcium caseinate and trimethylsilyl isocyanate could be linked in chemical synthesis, where trimethylsilyl isocyanate might be used to modify the surface of calcium caseinate for creating novel biomaterials, such as controlled-release drug delivery systems or protein-based coatings.

Purification Methods

Purify it by repeated fractionation as for the isothiocyanate. [Eaborn J Chem Soc 3077 1950, Beilstein 4 III 1861, 4 IV 4011.]

Trimethylsilyl Isocyanate(1118-02-1)Related Product Information

• TriMethyl(broModifluoroMethyl)silane
• Trimethylboroxine
• Ethyl trifluoroacetate
• Ethyl 4,4,4-trifluoroacetoacetate
• Trimethoxy(pentamethylcyclopentadienyl) titanium(IV)
• Propyl isocyanate
• TRIMETHYLSILYL ISOTHIOCYANATE
• triethyl(3-isocyanatopropyl)silane
• TRIMETHYLSILYL ISOCYANATE