TRIMETHYLSILYL ISOTHIOCYANATE
TRIMETHYLSILYL ISOTHIOCYANATE Basic information
- Product Name:
- TRIMETHYLSILYL ISOTHIOCYANATE
- Synonyms:
-
- isothiocyanatotrimethyl-silan
- Silane, isothiocyanatotrimethyl-
- TRIMETHYLSILYL ISOTHIOCYANATE
- ISOTHIOCYANATOTRIMETHYLSILANE
- Trimethylsilylisothiocyanate,94%
- Trimethylsilyl isothiocyanate,97%
- (TriMethylsilyl)isothiocyanate 99%
- Trimethylsilyl Isothicyanate
- CAS:
- 2290-65-5
- MF:
- C4H9NSSi
- MW:
- 131.27
- EINECS:
- 218-929-7
- Mol File:
- 2290-65-5.mol
TRIMETHYLSILYL ISOTHIOCYANATE Chemical Properties
- Melting point:
- −32.8 °C(lit.)
- Boiling point:
- 143 °C(lit.)
- Density
- 0.931 g/mL at 25 °C(lit.)
- vapor density
- >1 (vs air)
- refractive index
- n20/D 1.482(lit.)
- Flash point:
- 95 °F
- storage temp.
- 2-8°C
- form
- liquid
- Specific Gravity
- 0.931
- Water Solubility
- Reacts with water.
- Hydrolytic Sensitivity
- 8: reacts rapidly with moisture, water, protic solvents
- Sensitive
- Moisture Sensitive
- BRN
- 1745262
- InChIKey
- XLTUPERVRFLGLJ-UHFFFAOYSA-N
- CAS DataBase Reference
- 2290-65-5(CAS DataBase Reference)
- EPA Substance Registry System
- Isothiocyanatotrimethylsilane (2290-65-5)
Safety Information
- Hazard Codes
- T
- Risk Statements
- 10-23/24/25-36/37/38-42
- Safety Statements
- 23-26-36/37-45
- RIDADR
- UN 1992 3/PG 3
- WGK Germany
- 3
- F
- 10-19-21
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29319090
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
TRIMETHYLSILYL ISOTHIOCYANATE Usage And Synthesis
Chemical Properties
clear colorless to light yellow liquid
Uses
Trimethylsilyl isothiocyanate is used as derivatizing reagent during the synthesis of amino acid thiohydantoins. It participates in ring opening reaction of N-substituted aziridines and cyclohexene oxide.
Uses
Trimethylsilyl isothiocyanate was used as derivatizing reagent during the synthesis of amino acid thiohydantoins.
General Description
Trimethylsilyl isothiocyanate (TMS-ITC) reacts with fullerene-mixed peroxide C60(O)(OOtBu)4 to yield isothiocyanate derivative C60(NCS)(OH)(OOtBu)4. TMS-ITC undergoes condensation with ethyl 2-benzylamino-5-methyl-3-phenylcyclopent-1-enecarboxylate to yield 1-benzyl-5-methyl-7-phenyl-2-thioxo-1,2,3,5,6,7-hexahydrocyclopentapyrimidin-4-one. It participates in ring opening reaction of N-substituted aziridines and cyclohexene oxide.
Purification Methods
The 1H NMR spectrum should have only one peak; if not purify it by repeated fractionation in an all-glass system using a 50cm (4mm internal diameter) column without packing. [Anderson J Am Chem Soc 69 3049 1947, Fehér & Blümcke Chem Ber 90 1934 1957, Neidleim & Hege Synthesis 51 1975, Beilstein 4 III 1861, 4 IV 4011.]
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TRIMETHYLSILYL ISOTHIOCYANATE(2290-65-5)Related Product Information
- 4-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER
- Ethyl isonicotinate
- Isothiazolinones
- Benzyl isocyanate
- Ethoxycarbonyl Isothiocyanate
- Benzyl thiocyanate
- Trimethoxy(pentamethylcyclopentadienyl) titanium(IV)
- 3-FLUOROPHENYL ISOCYANATE
- 4-Fluorophenyl isocyanate
- Ethyl isocyanoacetate
- Isopropyl isothiocyanate
- 2-ETHOXYPHENYL ISOCYANATE
- Isobutyl isocyanate
- TRIMETHYLSILYL ISOCYANATE
- triethyl(3-isocyanatopropyl)silane
- TRIMETHYLSILYL ISOTHIOCYANATE
- isothiocyanic acid