Basic information Description Applications Safety Information Safety Supplier Related
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Isothiazolinones

Basic information Description Applications Safety Information Safety Supplier Related

Isothiazolinones Basic information

Product Name:
Isothiazolinones
Synonyms:
  • 4-Isothiazolin-3-one,5-chloro-2-methyl-
  • 5-chloro-2-methyl-3(2h)-isothiazolon
  • 5-chloro-2-methyl-4-isothiazolin-3-on
  • Isothiazolinone
  • 5-Chloro-2-methyl-4-isothiazolinone
  • 5-CHLORIDE-2-METHYL-4-ISOTHIAZOLINE-3-KETONE
  • 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE (CMI)
  • 5-CHLORO-2-METHYL-3(2H)-ISOTHIAZOLONE MIXED WITH 2-METHYL-3(2H)ISOTHIAZOLONE
CAS:
26172-55-4
MF:
C4H4ClNOS
MW:
149.6
EINECS:
247-500-7
Product Categories:
  • Antibacterial agent
  • plantgrowth
  • Industrial/Fine Chemicals
  • INORGANIC & ORGANIC CHEMICALS
  • Biocide
  • Heterocycles
  • Inhibitors
  • Sulfur & Selenium Compounds
  • Bactericide and Algicide
Mol File:
26172-55-4.mol
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Isothiazolinones Chemical Properties

Melting point:
42-45?C
Boiling point:
109.7°C
Density 
1.25 (14% aq.)
refractive index 
n20/D 1.378
storage temp. 
Refrigerator
pka
-4.06±0.40(Predicted)
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
26172-55-4(CAS DataBase Reference)
NIST Chemistry Reference
5-Chloro-2-methyl-3(2h)-isothiazolone(26172-55-4)
EPA Substance Registry System
5-Chloro-2-methyl-4-isothiazolin-3-one (26172-55-4)
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Safety Information

Hazard Codes 
C,N,T,Xn
Risk Statements 
34-43-50-20/21/22-50/53-23/24/25-42/43
Safety Statements 
26-36/37/39-45-60-61-24-28-36/37-23
RIDADR 
UN 1760 8/PG 2
WGK Germany 
1
RTECS 
NX8156850
HazardClass 
8
PackingGroup 
III
HS Code 
3808929090
Hazardous Substances Data
26172-55-4(Hazardous Substances Data)

MSDS

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Isothiazolinones Usage And Synthesis

Description

Isothiazolinone is a heterocyclic chemical compound related to isothiazole. Isothiazolinone is an antimicrobial preservative that is often used to control fungi, bacteria, and algae. Since water-containing solutions are the breeding grounds for bacteria, isothiazolinone can easily be used in such solutions.

Applications

Although isothiazolinones have no direct applications, their derivatives such as 5-chloro-2-methyl-4-isothiazolin-3-on and 2-methyl-4-isothiazolin-3 which are used together as preservatives in commercial households and cosmetics products, for instance, cleaners, shampoos, and washing materials. Notably, various products that use isothiazolinones are in the market, including shampoo, hand sanitizer, and lotions. Isothiazolinones is used in these products as an inhibitor of microbial activity that could lead to the product spoiling before the expected expiration date.

Safety Information

The recommended use of isothiazolinone products by the manufacturers used as wrinkle releaser is not harmful. However, allergy to skin is one of the most reported issue with isothiazolinone.

Description

Methy1chloro-isothiazolinone (MCI) is contained, along with methylisothiazolinone (MI), in Kathon cosmetic grade (CG) and MCI/MI. It is irritant and sensitizer.

Chemical Properties

Liquid

Uses

Isocil(R) MW-14 is a high performance biocide for preserving metal working fluids, hydraulic fluids, polymer emulsions, pigment dispersions. Suggested applications: preservative concentrate. Very low level.

Uses

Isocil(R) PC is a cost-effective antimicrobial for personal care formulations. Suggested applications: personal care preservative.

Uses

Isocil(R) RW is a high performance industrial microbiocide for use in recirculating water cooling towers, wood, mold and mildew control, pulp and paper mills, air washer systems. Suggested applications: Industrial water treatment. Very low use levels.

Uses

A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.

Definition

ChEBI: A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product KathonTM.

Isothiazolinones Preparation Products And Raw materials

Raw materials

IsothiazolinonesSupplier

Guangdong wengjiang Chemical Reagent Co., Ltd. Gold
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NORANA GROUP Gold
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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jkinfo@jkchemical.com