- Product Name:
- 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE (CMI)
- 5-CHLORO-2-METHYL-3(2H)-ISOTHIAZOLONE MIXED WITH 2-METHYL-3(2H)ISOTHIAZOLONE
- Product Categories:
- Antibacterial agent
- Industrial/Fine Chemicals
- INORGANIC & ORGANIC CHEMICALS
- Sulfur & Selenium Compounds
- Bactericide and Algicide
- Mol File:
Isothiazolinones Chemical Properties
- Melting point:
- Boiling point:
- 1.25 (14% aq.)
- refractive index
- n20/D 1.378
- storage temp.
- Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 26172-55-4(CAS DataBase Reference)
- NIST Chemistry Reference
- EPA Substance Registry System
- 5-Chloro-2-methyl-4-isothiazolin-3-one (26172-55-4)
- Language:English Provider:SigmaAldrich
Isothiazolinones Usage And Synthesis
Isothiazolinone is a heterocyclic chemical compound related to isothiazole. Isothiazolinone is an antimicrobial preservative that is often used to control fungi, bacteria, and algae. Since water-containing solutions are the breeding grounds for bacteria, isothiazolinone can easily be used in such solutions.
Although isothiazolinones have no direct applications, their derivatives such as 5-chloro-2-methyl-4-isothiazolin-3-on and 2-methyl-4-isothiazolin-3 which are used together as preservatives in commercial households and cosmetics products, for instance, cleaners, shampoos, and washing materials. Notably, various products that use isothiazolinones are in the market, including shampoo, hand sanitizer, and lotions. Isothiazolinones is used in these products as an inhibitor of microbial activity that could lead to the product spoiling before the expected expiration date.
The recommended use of isothiazolinone products by the manufacturers used as wrinkle releaser is not harmful. However, allergy to skin is one of the most reported issue with isothiazolinone.
Methy1chloro-isothiazolinone (MCI) is contained, along with methylisothiazolinone (MI), in Kathon cosmetic grade (CG) and MCI/MI. It is irritant and sensitizer.
Isocil(R) MW-14 is a high performance biocide for preserving metal working fluids, hydraulic fluids, polymer emulsions, pigment dispersions. Suggested applications: preservative concentrate. Very low level.
Isocil(R) PC is a cost-effective antimicrobial for personal care formulations. Suggested applications: personal care preservative.
Isocil(R) RW is a high performance industrial microbiocide for use in recirculating water cooling towers, wood, mold and mildew control, pulp and paper mills, air washer systems. Suggested applications: Industrial water treatment. Very low use levels.
A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.
ChEBI: A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product KathonTM.
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- Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
- Ethyl isonicotinate
- Ethyl Isocyanatoacetate
- 1-ADAMANTYL ISOCYANATE
- ISOCYANIC ACID
- m-Tolyl isocyanate
- TERT-BUTYL ISOCYANIDE
- Isoquinoline-5-sulphonyl chloride hydrochloride
- Ethoxycarbonyl Isothiocyanate
- Benzyl isocyanate
- TRIMETHYLSILYL ISOTHIOCYANATE
- 4-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER