Isothiazolinones
Isothiazolinones Basic information
- Product Name:
- Isothiazolinones
- Synonyms:
-
- 4-Isothiazolin-3-one,5-chloro-2-methyl-
- 5-chloro-2-methyl-3(2h)-isothiazolon
- 5-chloro-2-methyl-4-isothiazolin-3-on
- Isothiazolinone
- 5-Chloro-2-methyl-4-isothiazolinone
- 5-CHLORIDE-2-METHYL-4-ISOTHIAZOLINE-3-KETONE
- 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE (CMI)
- 5-CHLORO-2-METHYL-3(2H)-ISOTHIAZOLONE MIXED WITH 2-METHYL-3(2H)ISOTHIAZOLONE
- CAS:
- 26172-55-4
- MF:
- C4H4ClNOS
- MW:
- 149.6
- EINECS:
- 247-500-7
- Product Categories:
-
- Antibacterial agent
- plantgrowth
- Industrial/Fine Chemicals
- INORGANIC & ORGANIC CHEMICALS
- Biocide
- Heterocycles
- Inhibitors
- Sulfur & Selenium Compounds
- Bactericide and Algicide
- 26172-55-4
- Mol File:
- 26172-55-4.mol
Isothiazolinones Chemical Properties
- Melting point:
- 42-45?C
- Boiling point:
- 109.7°C
- Density
- 1.25 (14% aq.)
- refractive index
- n20/D 1.378
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- -4.06±0.40(Predicted)
- form
- Liquid
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- LogP
- 0.240 (est)
- CAS DataBase Reference
- 26172-55-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 5-Chloro-2-methyl-3(2h)-isothiazolone(26172-55-4)
- EPA Substance Registry System
- 5-Chloro-2-methyl-4-isothiazolin-3-one (26172-55-4)
Safety Information
- Hazard Codes
- C,N,T,Xn
- Risk Statements
- 34-43-50-20/21/22-50/53-23/24/25-42/43
- Safety Statements
- 26-36/37/39-45-60-61-24-28-36/37-23
- RIDADR
- UN 1760 8/PG 2
- WGK Germany
- 1
- RTECS
- NX8156850
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 3808929090
- Hazardous Substances Data
- 26172-55-4(Hazardous Substances Data)
MSDS
- Language:English Provider:SigmaAldrich
Isothiazolinones Usage And Synthesis
Description
Isothiazolinone is a heterocyclic chemical compound related to isothiazole. Isothiazolinone is an antimicrobial preservative that is often used to control fungi, bacteria, and algae. Since water-containing solutions are the breeding grounds for bacteria, isothiazolinone can easily be used in such solutions.
Applications
Although isothiazolinones have no direct applications, their derivatives such as 5-chloro-2-methyl-4-isothiazolin-3-on and 2-methyl-4-isothiazolin-3 which are used together as preservatives in commercial households and cosmetics products, for instance, cleaners, shampoos, and washing materials. Notably, various products that use isothiazolinones are in the market, including shampoo, hand sanitizer, and lotions. Isothiazolinones is used in these products as an inhibitor of microbial activity that could lead to the product spoiling before the expected expiration date.
Safety Information
The recommended use of isothiazolinone products by the manufacturers used as wrinkle releaser is not harmful. However, allergy to skin is one of the most reported issue with isothiazolinone.
Description
Methy1chloro-isothiazolinone (MCI) is contained, along with methylisothiazolinone (MI), in Kathon cosmetic grade (CG) and MCI/MI. It is irritant and sensitizer.
Chemical Properties
Liquid
Uses
Isocil(R) MW-14 is a high performance biocide for preserving metal working fluids, hydraulic fluids, polymer emulsions, pigment dispersions. Suggested applications: preservative concentrate. Very low level.
Uses
Isocil(R) PC is a cost-effective antimicrobial for personal care formulations. Suggested applications: personal care preservative.
Uses
Isocil(R) RW is a high performance industrial microbiocide for use in recirculating water cooling towers, wood, mold and mildew control, pulp and paper mills, air washer systems. Suggested applications: Industrial water treatment. Very low use levels.
Uses
A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.
Definition
ChEBI: A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product KathonTM.
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Isothiazolinones(26172-55-4)Related Product Information
- Methanol
- Paraquat dichloride
- Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
- Methylparaben
- Kresoxim-methyl
- Acetonitrile
- 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
- Basic Violet 1
- Methyl acetate
- Methyl acrylate
- Isovanillin
- 1-ADAMANTYL ISOCYANATE
- 2-Isocyanatoethyl Acrylate
- ISOCYANIC ACID
- m-Tolyl isocyanate
- TERT-BUTYL ISOCYANIDE
- Isoquinoline-5-sulphonyl chloride hydrochloride
- Methyl