Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Cyanate ester / isocyanate >  TERT-BUTYL ISOCYANIDE

TERT-BUTYL ISOCYANIDE

Basic information Safety Supplier Related

TERT-BUTYL ISOCYANIDE Basic information

Product Name:
TERT-BUTYL ISOCYANIDE
Synonyms:
  • 2-ISOCYANO-2-METHYL-PROPANE
  • TERT-BUTYL ISOCYANIDE
  • TERT-BUTYL ISONITRILE
  • T-BUTYLISOCYANIDE
  • (CH3)3CNC
  • 2-isocyano-2-methyl-propan
  • 2-Methyl-2-isocyanopropane
  • Propane, 2-isocyano-2-methyl-
CAS:
7188-38-7
MF:
C5H9N
MW:
83.13
EINECS:
230-553-5
Product Categories:
  • organic compound
  • Isocyanides
  • Nitrogen Compounds
  • Organic Building Blocks
Mol File:
7188-38-7.mol
More
Less

TERT-BUTYL ISOCYANIDE Chemical Properties

Melting point:
148-150 °C
Boiling point:
91 °C(lit.)
Density 
0.735 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.376(lit.)
Flash point:
-2 °C
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in organic solvents such as ethanol, methanol, ether, toluene and dichloromethane.
form 
liquid
color 
colorless
Specific Gravity
0.735
BRN 
1903156
Exposure limits
NIOSH: IDLH 25 mg/m3
Stability:
store cold
CAS DataBase Reference
7188-38-7(CAS DataBase Reference)
More
Less

Safety Information

Hazard Codes 
F,T
Risk Statements 
11-23-2017/11/23
Safety Statements 
16-45
RIDADR 
UN 1993 3/PG 2
WGK Germany 
3
RTECS 
EQ7102500
HazardClass 
3
PackingGroup 
II
HS Code 
29299090

MSDS

More
Less

TERT-BUTYL ISOCYANIDE Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

tert-Butyl isocyanide is used in a tin-free procedure for alkyl radical reactions in the presence of a free-radical initiator. It is a useful intermediate in multicomponent reactions. It is also used in the synthesis of coumarines, 4H-chromenes, isoxazolines and to trap 2-cyclopropylidene-1,3-diones.

Preparation

CAUTION: Use a well-ventilated hood and observe all precautions when using hydrogen cyanide.
To a 1-1, stainless steel Hoke pressure cylinder in a well-ventilated hood is added 196 gm (3.5 moles) of isobutene, 95 gm (3.5 moles) of hydrogen cyanide, and 100 gm (0.7 mole) or cuprous bromide. The cylinder is closed, shaken for 15 hr at 70°C, cooled to room temperature, and vented cautiously in the hood, and the viscous residue is poured slowly into aqueous potassium cyanide (260 gm in 100 ml of water) to decompose the cuprous complex, liberating an organic layer. The organic layer is separated, dried, and distilled under reduced pressure to afford 97 gm, b.p. 60-63°C (314 mm Hg), ng 1.3749, IR 2143 s, 1472 m, 1368 m, 1230 m, 1208 m, 855 w c m - 1; yield, 33% based on starting isobutylene; 16% based on CuBr.

Preparation

Phosgene (1.0 kg, 10.1 mol) was delivered through a wide tube into a stirred solution of N-t-butylformamide (1.01 kg, 10.0 mol) in triethylamine (1.30 kg) and o-dichlorobenzene (7.0 L) in a flask fitted with a reflux condenser charged with a freezing mixture of ice and salt (-20 C°). Water was added, the layers were separated, and the non-aqueous layer was dried over anhydrous potassium carbonate or magnesium sulfate and fractionated; bp 90–92 C°/750 mmHg; yield: 681 g (82%).

General Description

Carbon dative bond formation by tert-butyl isocyanide on the germanium (100) surface has been reported. It also forms complexes with metals and inserts into metal-carbon bonds to form iminoacyls.

TERT-BUTYL ISOCYANIDE Preparation Products And Raw materials

Raw materials

TERT-BUTYL ISOCYANIDESupplier

Zhengzhou Kingsfine Chemical Co., Ltd. Gold
Tel
0371-56632527 13838252817
Email
sales@kingsfine.com
Jinan Shangbo Biological Co., Ltd. Gold
Tel
0531-61320525 15866703830
Email
495745175@qq.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
PharmaBlock Sciences (Nanjing),Inc.
Tel
400-0255188 13770978108
Email
sales@pharmablock.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com