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TRICAPRIN

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TRICAPRIN Basic information

Product Name:
TRICAPRIN
Synonyms:
  • GLYCEROL TRIDECANOATE
  • GLYCERINTRICAPRATE
  • 1,2,3-TRIDECANOYLGLYCEROL
  • 1,2,3-TRIDECANOYL-RAC-GLYCEROL
  • glyceroltricaprin
  • glyceryltricaprate
  • Tricapric glyceride
  • tricapricglyceride
CAS:
621-71-6
MF:
C33H62O6
MW:
554.84
EINECS:
210-702-0
Mol File:
621-71-6.mol
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TRICAPRIN Chemical Properties

Melting point:
31-32 °C
Boiling point:
254 °C / 5mmHg
Density 
approximate 0.98 g/ml (20℃)
refractive index 
approximate 1.44
Flash point:
20 °C
storage temp. 
-20°C
solubility 
Chloroform (Sparingly), DMSO (Slightly, Sonicated)
form 
Solid
color 
White to Off-White
BRN 
1717683
InChIKey
LADGBHLMCUINGV-UHFFFAOYSA-N
LogP
12.444 (est)
CAS DataBase Reference
621-71-6(CAS DataBase Reference)
EPA Substance Registry System
Glycerol tridecanoate (621-71-6)
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Safety Information

Hazard Codes 
F,Xn
Risk Statements 
11-20/21/22
Safety Statements 
26-28
RIDADR 
UN 1282 3/PG 2
WGK Germany 
-
RTECS 
HE0100000
HS Code 
29171900

MSDS

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TRICAPRIN Usage And Synthesis

Description

1,2,3-Tridecanoyl glycerol is a triacylglycerol that contains decanoic acid at the sn-1, sn-2, and sn-3 positions. It has been found in human breast milk. 1,2,3-Tridecanoyl glycerol has been used as a standard for the quantification of triacylglycerols in fish oils by RP-HPLC. Formulations containing 1,2,3-tridecanoyl glycerol have been used in cosmetic products as thickening and skin-conditioning agents.

Uses

Tricaprin is used to construct solid lipid nanoparticles (SLNs) as delivery system for bromocriptine (B682600, Mesylate salt). It is also used in cationic SLNs to enhance p53 tumor suppressor gene transfer to lung cancer cells.

Definition

ChEBI: A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by capric (decanoic) acid.

in vivo

Trisdecanoin (Intravenous injection (i.v.); 1h, 4h) can promote the metabolism of long chain fatty acids (LCFA) in the heart muscle of Atgl KO mice in lipotriglyceride lipase (Atgl) gene knockout (KO) mice. Effect of reducing lipid accumulation in the heart of AtglKO mice and improving left ventricular function of AtglKO mice[2].
Trisdecanoin (1145 mg/kg/day; Oral gavage (p.o.); two weeks) can prevent and inhibit the development of abdominal aortic aneurysms and alleviate the apoptosis and dysfunction of early smooth muscle cells (SMCs) in Male Sprague-Dawley rat models[3].

Animal Model:Male Sprague-Dawley rats[3]
Dosage:1145 mg/kg/day
Administration:Oral gavage (p.o.)
Result:There was no significant difference in the incidence of AAA between the control and ricaprylin groups (30.2% vs 24.0%). In contrast, the incidence of AAA in Trisdecanoin was significantly lower than in the control group (30.2% vs. 3.6%).
The AAA rupture rates in control group and C8-TG group were 31.3% and 33.3%, respectively. There was no aneurysm rupture in Trisdecanoin group.
The mean aortic diameter of Trisdecanoin group was significantly lower than that of control group..

References

[1] KIM K M, PARK T S, SHIM S M. Optimization and validation of HRLC-MS method to identify and quantify triacylglycerol molecular species in human milk[J]. Analytical Methods, 2015, 10: 4362-4370. DOI: 10.1039/c5ay00591d
[2] áNGELA GARCíA SOLAESA. Characterization of triacylglycerol composition of fish oils by using chromatographic techniques.[J]. Journal of oleo science, 2014, 63 5: 449-460. DOI: 10.5650/jos.ess13202
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

TRICAPRINSupplier

J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Email
market03@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Email
Sales-CN@TCIchemicals.com
Qingdao Vochem Co., Ltd.
Tel
532-88066095 18661779210
Email
vochem@vochem.com
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