2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Basic information
- Product Name:
- 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
- Synonyms:
-
- REMACEMIDE HYDROCHLORIDE
- 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
- RemacemideHCl
- 2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride
- 2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid
- 2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-
- fpl12924aa
- pr934-423a
- CAS:
- 111686-79-4
- MF:
- C17H21ClN2O
- MW:
- 304.82
- Mol File:
- 111686-79-4.mol
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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Chemical Properties
- Melting point:
- 253-254°
- storage temp.
- room temp
- solubility
- H2O: >10mg/mL
- form
- powder
- color
- white to beige
- Water Solubility
- Soluble to 100 mM in water
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Safety Information
- Hazard Codes
- Xn,N
- Risk Statements
- 22-41-50/53
- Safety Statements
- 26-39-45-60-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- RTECS
- AB4349500
- Toxicity
- LD50 (calculated as base) in rats (mg/kg): ~50 i.v., ~900 orally (Muir, Palmer)
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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE Usage And Synthesis
Uses
Anticonvulsant (neuroprotective).
Biological Activity
Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC 50 = 8-68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na + channels (IC 50 = 161 mM).
Biochem/physiol Actions
Remacemide HCl is a low affinity NMDA antagonist with anticonvulsant properties. Remacemide also been shown to block voltage-dependent sodium channels.
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDESupplier
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