Roquinimex Chemical Properties

Melting point:

200-204°

Boiling point:

436.2±45.0 °C(Predicted)

Density 

1.357±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO: 11 mg/mL

form 

solid

pka

4.50±1.00(Predicted)

color 

White to off-white

Merck 

14,8259

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36/37

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

HS Code 

2933.49.2600

MSDS

• Language:English Provider:SigmaAldrich

Roquinimex Usage And Synthesis

Description

Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model.

Uses

Biological response modifier; immunomodulator.

Uses

An immunomodulator with antitumour properties. Inhibits T-cell apoptosis in vivo; also inhibits angiogenesis in rats

Definition

ChEBI: 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide is an aromatic amide.

Biological Activity

Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo .

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