DM3-Sme Chemical Properties

Boiling point:

962.6±65.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

9.82±0.70(Predicted)

DM3-Sme Usage And Synthesis

Description

DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

References

[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.