(-)-MK-801 MALEATE Chemical Properties

Melting point:

208.5-210°

alpha 

D20 +114° (c = 0.0128 g/2 ml ethanol)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO: >20 mg/mL

form 

solid

color 

white

optical activity

[α]25/D +117°, c = 1 in methanol(lit.)

InChIKey

QLTXKCWMEZIHBJ-FWHYOZOBSA-N

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

HP1093575

MSDS

• Language:English Provider:SigmaAldrich

(-)-MK-801 MALEATE Usage And Synthesis

Uses

Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.

Uses

(-)-MK-801 MALEATE is probe for NMDA receptors

Uses

(-)-MK-801 MALEATE acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.

Definition

ChEBI: Dizocilpine maleate is a maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid. It has a role as an anaesthetic, an anticonvulsant, a neuroprotective agent, a nicotinic antagonist and a NMDA receptor antagonist. It is a maleate salt and a tetracyclic antidepressant. It contains a dizocilpine(1+).

General Description

A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca²⁺ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca²⁺ entry induced seizures.

Biological Activity

(-)-MK-801 MALEATE is a potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux. An effective anti-ischemic agent in several animal models. Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Primary TargetNMDA receptor

storage

Room temperature

References

[1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8.

(-)-MK-801 MALEATE(77086-22-7)Related Product Information

• (-)-MK 801 MALEATE, >99%
• (-)-MK-801 MALEATE
• (+)-MK 801 MALEATE,(-)-MK 801 MALEATE