4-CHLORO-3-IODOPYRIDINE Chemical Properties

Melting point:

69-70°C

Boiling point:

248.6±20.0 °C(Predicted)

Density 

2.052±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

1.89±0.10(Predicted)

Appearance

Off-white to light yellow Solid

InChI

InChI=1S/C5H3ClIN/c6-4-1-2-8-3-5(4)7/h1-3H

InChIKey

GPFGRYFMMHDHGA-UHFFFAOYSA-N

SMILES

C1=NC=CC(Cl)=C1I

Safety Information

Hazard Codes 

Xi,N,Xn

Risk Statements 

22-38-41-50

Safety Statements 

26-39-61

RIDADR 

3077

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

2933399990

4-CHLORO-3-IODOPYRIDINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 4-chloro-3-iodopyridine from 4-chloropyridine was as follows: suspension of 4-chloropyridine (10 g, 0.067 mol) in dry THF (150 mL) and slow dropwise addition of LDA (134 mL, 1 M hexane solution) at a temperature below -70 °C. The reaction mixture was stirred at -78 °C for 30 min before adding an anhydrous THF solution of I2 (17 g, 0.067 mol), keeping the internal temperature below -65 °C for 10 min. Subsequently, the reaction mixture was slowly warmed up to room temperature over a period of 2 hours and stirring was continued at room temperature for 30 minutes. Upon completion of the reaction, the mixture was poured into 20% aqueous Na2SO3 solution (100 mL) and extracted with EtOAc (100 mL, three times). The organic layer was washed sequentially with aqueous NaHCO3 (50 mL) and saturated aqueous NaCl (50 mL), dried and the solvent was evaporated. The product was purified by washing with petroleum ether (20 mL) to give 4-chloro-3-iodopyridine (6.2 g, 38% yield).'' HNMR (400 MHz, MeOD) δ 8.92 (s, 1H), 8.43-8.41 (d, 1H, J = 8Hz), 7.62-7.60 (d, 1H, J = 8Hz).

References

[1] Tetrahedron Letters, 2004, vol. 45, # 42, p. 7873 - 7877
[2] Journal of the American Chemical Society, 2002, vol. 124, # 4, p. 576 - 582
[3] Patent: WO2013/78254, 2013, A1. Location in patent: Paragraph 00359
[4] Heterocycles, 1996, vol. 43, # 8, p. 1641 - 1652

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