GUANOSINE 5'-DIPHOSPHATE TRIS SALT Chemical Properties

storage temp. 

-20°C

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

GUANOSINE 5'-DIPHOSPHATE TRIS SALT Usage And Synthesis

Uses

Guanosine 5'-diphosphate ditromethamine is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate ditromethamine is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate ditromethamine can be used in the research of inflammation, such as anemia of inflammation (AI)[1][2].

Biochem/physiol Actions

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.

IC 50

Human Endogenous Metabolite

References

[1] S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. DOI:10.1113/jphysiol.1991.sp018885
[2] Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097. DOI:10.1038/srep40097

GUANOSINE 5'-DIPHOSPHATE TRIS SALT(103192-39-8)Related Product Information

• 5'-Guanylic acid
• GTP TRIS SALT
• TRIS(HYDROXYMETHYL)AMINOMETHANE PHOSPHATE
• 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE AMMONIUM SALT
• 2',3'-dideoxyguanosine 5'-diphosphate
• 2'-DEOXYGUANOSINE 5'-MONOPHOSPHATE
• GUANOSINE 5'-TETRAPHOSPHATE TRIS SALT
• GUANOSINE 5'-DIPHOSPHATE TRIS SALT
• GDP
• Guanosine
• IMP