Lynestrenol Chemical Properties

Melting point:

158°C

alpha 

D -13° (chloroform)

Boiling point:

366.92°C (rough estimate)

Density 

1.0083 (rough estimate)

refractive index 

1.4500 (estimate)

storage temp. 

2-8°C

solubility 

Practically insoluble in water, soluble in acetone and in ethanol (96 per cent).

pka

13.12±0.40(Predicted)

form 

Solid

color 

Crystals from MeOH

Merck 

14,5629

CAS DataBase Reference

52-76-6

EPA Substance Registry System

Lynestrenol (52-76-6)

Safety Information

RTECS 

RC8964300

HS Code 

2937230000

Hazardous Substances Data

52-76-6(Hazardous Substances Data)

Lynestrenol Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Uses

Lynestrenol is an orally available progestogen hormone used in contraception to avoid hereditary angiodema as well as in treatment of ischemic stroke.

Uses

Progestogen;Antioestrogen

Definition

ChEBI: Lynestrenol is a steroid. It derives from a hydride of an estrane.

brand name

Anacycline 101;Anacylin 101;Anacylin 28;Ancylin;Athilyn;Endometril;Exluton (a);Fysiognens;Fysionorm;Gestrol;Lindiol 2.5;Lyn_ratiopharm;Lyn_ratiophram_sequenz;Lyndeol;Lyndile tt;Lyndiol e.;Lyndiolett;Lynoenstrenol;Lyn-ratiopharm;Mini pregnon;Minifol;Minilyn;Neo lyndiol;Neo-lindiol;Neo-lynobol;Nonovulet;Noracyclin 22;Normophasic;Novostat;Org 485-50;Orgaluton;Orgametrol;Ovamezzo;Ovanone;Ovanon-e;Ovariostat;Ovoresta micro;Ovostat-28;Ovostat-micro;Phasicon;Physiostat;Physistat;Pregnon-28;Restovar.

World Health Organization (WHO)

Lynestrenol, a synthetic progestogen, was introduced in the early 1960s as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, lynestrenol was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by at least one regulatory authority. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and lynestrenol remains available in some countries for contraceptive and other purposes. (Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)

Safety Profile

An experimental teratogen.Experimental reproductive effects. Human reproductiveeffects by ingestion and implant routes: menstrual cyclechanges or disorders, female fertility index, other fertilitychanges and effects on females. Questionable carcinoge

Lynestrenol (52-76-6)Related Product Information

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• 4-ESTREN-17-ALPHA-ETHYNYL-6-BETA, 17-BETA-DIOL-3-ONE