3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties

Boiling point:

357.6±32.0 °C(Predicted)

Density 

1.319

storage temp. 

Sealed in dry,Room Temperature

pka

9.62±0.48(Predicted)

Appearance

Colorless to light yellow Liquid

3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Usage And Synthesis

Uses

Ethyl 3-(3,4-dichlorophenyl)-3-oxopropionate is an organic intermediate, which has been reported in the literature to prepare α-ketoamides and their derivatives.

Preparation

React with 3,4-dichlorobenzaldehyde, ethyl diazoacetate and ter-BuOK, and then directly separate the resulting mixture by silica gel flash column chromatography to obtain Ethyl 3-(3,4-dichlorophenyl)-3-oxopropionate.

Synthesis

1. CDI (41.5 g, 290.32 mmol, 3.70 eq.) was added to a solution of 3,4-dichlorobenzoic acid (15 g, 78.53 mmol, 1.00 eq.) in tetrahydrofuran (200 mL) under dry conditions. The reaction mixture was stirred at 25 °C for 4 hours. 2. In another reaction flask, monoethyl malonate potassium salt (37.7 g, 235 mmol, 3.00 eq.) was dissolved in acetonitrile (400 mL), followed by the addition of MgCl2 (33.5 g, 353 mmol, 4.5 eq.) and triethylamine (23.8 g, 235 mmol, 3.00 eq.). 3. The solutions from Steps 1 and 2 were combined and the reaction was stirred at room temperature for 2 hours. 4. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. 5. The concentrated residue was diluted with 200 mL of water and the pH was adjusted to 5 with 1 M HCl. 6. The aqueous phase was extracted with ethyl acetate (4 x 50 mL), the organic layers were combined and dried with anhydrous magnesium sulfate. 7. After filtering the desiccant, the organic phase was concentrated under reduced pressure. 8. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate (50:1) as eluent. 9. 15 g (73% yield) of ethyl 3-(3,4-dichlorophenyl)-3-oxopropanoate was finally obtained as a colorless oil.

References

[1] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175

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