(E,E)-2-[(DIHYDROXYPHOSPHINYL)METHYL]-3-OXO-3-[(3,7,11-TRIMETHYL-2,6,10-DODECATRIENYL)-AMINO]PROPANOIC ACID, 3NA Chemical Properties

storage temp. 

-70°C

solubility 

water: ≥10 mg/mL

form 

solid

color 

white

Water Solubility 

water: ≥10mg/mL

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2

(E,E)-2-[(DIHYDROXYPHOSPHINYL)METHYL]-3-OXO-3-[(3,7,11-TRIMETHYL-2,6,10-DODECATRIENYL)-AMINO]PROPANOIC ACID, 3NA Usage And Synthesis

Uses

A highly selective and potent inhibitor of Ras farnesyltransferase (IC₅₀ = 83 nM). Inhibits geranylgeranyltransferase I (IC₅₀ = 26 µM) and II (IC₅₀ = 47 µM) at much higher concentrations.
Potent and highly selective inhibitor of farnesyltransferase (FTase; IC₅₀ = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC₅₀ = 26 µM and 47 µM for GGTase I and II, respectively).
The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

Biological Activity

Primary Target
Farnesyltransferase (Ftase)', 'Product does not compete with ATP.', 'Target IC50: 83 nM against Ftase