WNK inhibitor 7
WNK inhibitor 7 Basic information
- Product Name:
- WNK inhibitor 7
- Synonyms:
-
- WNK inhibitor 7
- WNK IN 7
- WNKIN7
- WNK-IN-7
- 1H-Indole-3-methanamine, 1-[2-(3-methoxyphenyl)-5-methyl-4-pyridinyl]-N-(2-methylpropyl)-
- CAS:
- 2125724-72-1
- MF:
- C26H29N3O
- MW:
- 399.53
- Mol File:
- 2125724-72-1.mol
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WNK inhibitor 7 Chemical Properties
- Boiling point:
- 573.3±50.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- pka
- 9.86±0.29(Predicted)
- form
- Solid
- color
- White to off-white
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WNK inhibitor 7 Usage And Synthesis
Description
WNK-IN-7 is a potent and selectiive inhibitor of WNK1 kinase.
Uses
WNK-IN-1 (compound 7) is a ATP noncompetitive With-No-Lysine (WNK) kinase inhibitor (IC50=95 nM). WNK-IN-1 can be used to regulate cardiovascular homeostasis[1].
References
[1] Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60(16):7099-7107. DOI:10.1021/acs.jmedchem.7b00708
WNK inhibitor 7Supplier
TargetMol Chemicals Inc.
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Nanjing Shizhou Biology Technology Co.,Ltd
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- 025-85560043 15850508050
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TargetMol Chemicals Inc.
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- 15002134094
- marketing@targetmol.cn
TargetMol Chemicals Inc.
- Tel
- +17819995354
- marketing@targetmol.com