Allosteric WNK Kinase Inhibitor ,
Allosteric WNK Kinase Inhibitor , Basic information
- Product Name:
- Allosteric WNK Kinase Inhibitor ,
- Synonyms:
-
- ALLOSTERIC WNK KINASE INHIBITOR
- Allosteric WNK Kinase Inhibitor ,
- WNK-IN-11
- WNK-IN-11; WNK IN 11; WNKIN11; WNK INHIBITOR 11; WNK INHIBITOR-11;2123489-30-3
- (5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone
- Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-
- Threonine proteases,inhibit,WNKIN11,Serine proteases,Serine endopeptidases,Inhibitor,Ser/Thr Protease,WNK IN 11
- WNK-IN-11, 10 mM in DMSO
- CAS:
- 2123489-30-3
- MF:
- C21H21Cl2N5OS
- MW:
- 462.4
- Mol File:
- 2123489-30-3.mol
More
Less
Allosteric WNK Kinase Inhibitor , Chemical Properties
- Boiling point:
- 641.1±65.0 °C(Predicted)
- Density
- 1.407±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml
- form
- A crystalline solid
- pka
- 5.52±0.10(Predicted)
- color
- White to off-white
More
Less
Allosteric WNK Kinase Inhibitor , Usage And Synthesis
Uses
WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.
References
[1] Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60(16):7099-7107. DOI:10.1021/acs.jmedchem.7b00708
Allosteric WNK Kinase Inhibitor ,Supplier
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
Shanghai JiYi Biotechnology Co. Ltd.
- Tel
- 13621943973
- sales@shjiyipharmatech.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com