BI-409306 Chemical Properties

Boiling point:

559.8±60.0 °C(Predicted)

Density 

1.48±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:62.0(Max Conc. mg/mL);199.14(Max Conc. mM)

form 

A crystalline solid

pka

3.94±0.12(Predicted)

color 

White to off-white

BI-409306 Usage And Synthesis

Uses

Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.

IC 50

PDE9A: 52 nM (IC₅₀); PDE1C: 1 μM (IC₅₀); PDE1A: 1.4 μM (IC₅₀)

References

[1] Cornelia Dorner-Ciossek, et al. BI 409306, a novel phosphodiesterase 9A inhibitor, part I: potency, selectivity and in-vitro functional characterization on synaptic plasticity. International Congress on Schizophrenia Research.