UT-155
UT-155 Basic information
- Product Name:
- UT-155
- Synonyms:
-
- UT-155
- 1H-Indole-1-propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-5-fluoro-α-hydroxy-α-methyl-, (αS)-
- UT-155,Inhibitor,UT155,inhibit,Androgen Receptor,UT 155
- UT-155, 10 mM in DMSO
- (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(5-fluoro-1H-indol-1-yl)-2-hydroxy-2-methylpropanamide
- CAS:
- 2031161-35-8
- MF:
- C20H15F4N3O2
- MW:
- 405.35
- Mol File:
- 2031161-35-8.mol
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UT-155 Chemical Properties
- Boiling point:
- 613.6±55.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);246.7(Max Conc. mM)
- pka
- 12.74±0.29(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1/C20H15F4N3O2/c1-19(29,11-27-7-6-12-8-14(21)3-5-17(12)27)18(28)26-15-4-2-13(10-25)16(9-15)20(22,23)24/h2-9,29H,11H2,1H3,(H,26,28)/t19-/s3
- InChIKey
- CFSAYQVTXBMPRF-DETXXQSHNA-N
- SMILES
- C(N1C=CC2=CC(F)=CC=C12)[C@@](O)(C)C(=O)NC1C=CC(C#N)=C(C(F)(F)F)C=1 |&1:11,r|
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UT-155 Usage And Synthesis
Uses
UT-155 is a selective and potent androgen receptor (AR) antagonist, with a Ki of 267 nM for UT-155 binding to AR-LBD.
in vivo
Consistent with the anti-proliferative effects in vitro, UT-155 significantly inhibits the growth of 22RV1 xenograft by 53%, while, as expected, enzalutamide has no effect on the growth of the 22RV1 tumors. Tumor weights and PSA and the expression of AR and AR-SV are significantly lower in UT-155-treated animals[1].
References
[1] Ponnusamy S, et al. Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer. Cancer Res. 2017 Nov 15;77(22):6282-6298. DOI:10.1158/0008-5472.CAN-17-0976
UT-155Supplier
Chengdu Celes Technology Co., Ltd Gold
- Tel
- 19982073091
- 2538834896@qq.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Bide Pharmatech Ltd.
- Tel
- 400-164-7117 13681763483
- product02@bidepharm.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com