BAY-545 Chemical Properties

Boiling point:

598.7±60.0 °C(Predicted)

Density 

1.410±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:129.0(Max Conc. mg/mL);297.61(Max Conc. mM)
Ethanol:87.0(Max Conc. mg/mL);200.72(Max Conc. mM)

form 

A solid

pka

14.56±0.20(Predicted)

color 

White to off-white

BAY-545 Usage And Synthesis

Uses

BAY-545 is a potent and selective A2B adenosine receptor antagonist, with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2B adenosine receptor in cells, respectively, and a Ki of 97 nM for human A2B adenosine receptor, with more selectivity over A1, A2A, and A3 adenosine receptor[1].

References

[1] H?rter M, et al. Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structure. Eur J Med Chem. 2019 Feb 1;163:763-778. DOI:10.1016/j.ejmech.2018.11.045