Sulindac EP Impurity C-d3 (Sulindac Sulfide-d3)
Sulindac EP Impurity C-d3 (Sulindac Sulfide-d3) Basic information
- Product Name:
- Sulindac EP Impurity C-d3 (Sulindac Sulfide-d3)
- Synonyms:
-
- Sulindac EP Impurity C-d3 (Sulindac Sulfide-d3)
- SulindacEPImpurityC-d3
- Sulindac EP Impurity C-d3 (Sulindac USP Related Compound C-d3, Sulindac Sulfide-d3)
- D3-Sulindac Sulfide
- CAS:
- 250608-66-3
- MF:
- C20H17FO2S
- MW:
- 340.41
- Mol File:
- 250608-66-3.mol
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Sulindac EP Impurity C-d3 (Sulindac Sulfide-d3) Usage And Synthesis
Uses
Sulindac sulfide-d3 is deuterium labeled Sulindac sulfide. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Takahashi Y, et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J Biol Chem. 2003 May 16;278(20):18664-70. DOI:10.1074/jbc.M301619200
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