RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Chemical Properties

Melting point:

220°C dec.

storage temp. 

-20°C Freezer

solubility 

Aqueous Acid (Slightly), Water (Slightly, Sonicated)

form 

Solid

color 

Off-White to Pale Beige

Stability:

Hygroscopic

RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Usage And Synthesis

Description

Ribavirin 5''-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported K_i value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5''-monophosphate.

Chemical Properties

RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is Solid

Uses

A metabolite of Ribavirin.

Uses

RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is used as an antiviral agent

RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT(66983-94-6)Related Product Information

• Ribavirin