RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT
RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Basic information
- Product Name:
- RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT
- Synonyms:
-
- Ribavirin 5'-monophosphate (lithium salt)
- 1-(5-O-Phosphono-β-D-ribofuranosyl)-
- Ribavirin 5'-Monophosphate DilithiuM Salt (90%)
- RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT
- Ribavirin 5'-monophosphate (dilithium)
- Ribavirin 5'-monophosphate (lithium salt)
- Ribavirin 5’-Monophosphate Dilithium Salt (90%)
- CAS:
- 66983-94-6
- MF:
- C17H19Li2N4O9P
- MW:
- 468.21
- Product Categories:
-
- Bases & Related Reagents
- Carbohydrates & Derivatives
- Anti-virals
- Inhibitors
- Intermediates & Fine Chemicals
- Non-nucleoside Reverse Transcriptase
- Pharmaceuticals
- Metabolites & Impurities
- Nucleotides
- Mol File:
- Mol File
RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Chemical Properties
- Melting point:
- 220°C dec.
- storage temp.
- -20°C Freezer
- solubility
- Aqueous Acid (Slightly), Water (Slightly, Sonicated)
- form
- Solid
- color
- Off-White to Pale Beige
- Stability:
- Hygroscopic
RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT Usage And Synthesis
Description
Ribavirin 5''-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5''-monophosphate.
Chemical Properties
RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is Solid
Uses
A metabolite of Ribavirin.
Uses
RIBAVIRIN 5'-MONOPHOSPHATE, DILITHIUM SALT is used as an antiviral agent
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