CORALYNE CHLORIDE HYDRATE, 98+%
CORALYNE CHLORIDE HYDRATE, 98+% Basic information
- Product Name:
- CORALYNE CHLORIDE HYDRATE, 98+%
- Synonyms:
-
- 8-methyl-2,3,10,11-tetramethoxydibenzo(a,g)quinoliziniumchloride
- g)quinolizinium,8-methyl-2,3,10,11-tetramethoxy-dibenzo(chloride
- nsc96349
- CORALYNE CHLORIDE HYDRATE, 98+%
- coralyne chloride crystalline
- 2,3,10,11-tetramethoxy-8-methyldibenzo[a,g]quinolizinium chloride
- (-)-Coralyne chloride hydrate
- cancer,Topoisomerase,inhibit,neurodrug,Inhibitor,Coralyne,Coralyne chloride,Antileukemic,protoberberine,topoisomerase I
- CAS:
- 38989-38-7
- MF:
- C22H22ClNO4
- MW:
- 399.86738
- EINECS:
- 254-239-2
- Product Categories:
-
- Alkaloids
- Mol File:
- 38989-38-7.mol
CORALYNE CHLORIDE HYDRATE, 98+% Chemical Properties
- Melting point:
- 215°C
- storage temp.
- 2-8°C
- solubility
- DMSO:5.0(Max Conc. mg/mL);12.5(Max Conc. mM)
Water:5.0(Max Conc. mg/mL);12.5(Max Conc. mM) - form
- Solid
- color
- Light yellow to yellow
Safety Information
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-25
- Safety Statements
- 26-36-45
- RTECS
- HQ1812000
CORALYNE CHLORIDE HYDRATE, 98+% Usage And Synthesis
Chemical Properties
orange crystalline powder
Uses
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes[3].
IC 50
Topoisomerase I
References
[1] Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445. DOI:10.1016/j.biopha.2017.04.027
[2] D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4(6):781-91. DOI:10.1016/0968-0896(96)00054-5
[3] P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7(18):10660-10667. DOI:10.1039/c6ra27684a
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