6-Methoxyisoquinoline Chemical Properties

Boiling point:

88-95?C/0.8 Torr

Density 

1.130±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Dichloromethane

form 

Oil

pka

6.11±0.10(Predicted)

color 

Pale Yellow

CAS DataBase Reference

52986-70-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2933499090

6-Methoxyisoquinoline Usage And Synthesis

Chemical Properties

Clear Oil

Uses

6-Methoxy Isoquinoline (cas# 52986-70-6) is a compound useful in organic synthesis.

Preparation

6-Methoxyisoquinoline synthesis: Using benzaldehyde as the starting material, m-methoxybenzaldehyde is obtained through nitration, reduction, diazotization, hydrolysis and methylation, and 3-methoxybenzaldehyde is obtained through condensation with nitromethane Shiff base and reduction of aluminum hydride -p-Phenylethylamine. The Pictet-Spengler reaction of 3-methoxyl-p-phenylethylamine and 40% aqueous formaldehyde produces 6-methoxyl-1,2,3,4-tetrahydroisoquinoline, and then obtains the target compound in dehydrogenation 6-Methoxyisoquinoline.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 1939, 1947 DOI: 10.1021/ja01200a028

6-Methoxyisoquinoline(52986-70-6)Related Product Information

• 3-Methylisoquinoline
• 6-Methoxyquinoline
• Anisole
• 4-Methoxyphenylacetone
• 3-Methoxybenzaldehyde
• (Trifluoromethoxy)benzene
• Isoquinoline
• p-Anisidine
• p-Anisaldehyde
• 1-METHYLISOQUINOLINE
• 6-METHOXYQUINOXALINE
• 6-Methoxyisoquinolin-3-aMine
• 4-AMINO-6-METHOXYQUINOLINE
• 6-methoxyimidazo[1,2-a]pyridine-3-carbaldehyde
• IMidazo[1,2-a]pyridine,6-Methoxy-
• 6-METHOXY-QUINOLINE-2-CARBOXYLIC ACID
• 6-METHOXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• 6-METHOXY-QUINAZOLIN-4-YLAMINE