KENDOMYCIN Chemical Properties

Melting point:

236-240℃

Boiling point:

678.5±55.0 °C(Predicted)

Density 

1.19±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble in DMSO

form 

solid

pka

8.53±0.70(Predicted)

color 

Yellow

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

KENDOMYCIN Usage And Synthesis

Description

Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI₅₀ < 100 nM). It also acts as an endothelin receptor antagonist and has antiosteoporotic activities. Certain effects are thought to be mediated through inhibition of proteasomal degradation of proteins.

Uses

Kendomycin is an unusual macrocyclic metabolite containing a rare quinone methide group. Kendomycin is a potent antibacterial agent against Gram positive and Gram negative bacteria, including MRSA strains, also displaying antitumour activity. Kendomycin is a potent endothelin receptor agonist and demonstrates antiosteoporotic activity.

Uses

Kendomycin is a broadly efficacious polyketide macrocycle antibiotic.

Definition

ChEBI: Kendomycin is a member of benzofurans.

storage

+4°C

References

[1] KEVIN B. BAHNCK  Scott D R. Formal Synthesis of (?)-Kendomycin Featuring a Prins-Cyclization To Construct the Macrocycle[J]. Journal of the American Chemical Society, 2008, 130 39: 13177-13181. DOI: 10.1021/ja805187p