NPC1L1 Antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

Niemann-Pick C1-like 1 is a transmembrane protein that plays a critical role in cholesterol absorption. It is highly expressed in small intestine and localized along the brush border in both human and mouse epithelial cells. NPC1L1 mediates cholesterol uptake via vesicular endocytosis. Ezetimibe, a potent cholesterol absorption inhibitor used to treat hypercholesterolemia, inhibits cholesterol uptake by preventing NPC1L1 from incorporating into clathrin-coated vesicles.

References

[1] Altmann, S.W. et al. (2004) Science 303, 1201-4.
[2] Davis, H.R. et al. (2004) J Biol Chem 279, 33586-92.
[3] Sané, A.T. et al. (2006) J Lipid Res 47, 2112-20.
[4] Ge, L. et al. (2008) Cell Metab 7, 508-19.
[5] Davis, H.R. and Veltri, E.P. (2007) J Atheroscler Thromb 14, 99-108.