PCK2 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

PCK2 encodes an isoform of phosphoenolpyruvate carboxykinase that is found in the mitochondria of renal and hepatic tissues. PEPCK is involved in gluconeogenesis, the process of generating glucose from non-carbohydrate substrates such as lactate and glycerol. PEPCK catalyzes the reaction whereby oxaloacetate becomes phosphoenolpyruvate, a rate limiting step in the metabolic process. The predominant function of PCK2 is to process the lactate that is continually produced by red blood cells in the liver and kidney.

References

[1] Caton, P.W. et al. (2009) Life Sci 84, 738-44.
[2] Fischer, S. et al. (2010) Biol Reprod 83, 859-65.

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