Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Circulatory system drugs >  Antihypertensive drugs >  DELAPRIL

DELAPRIL

Basic information Safety Supplier Related

DELAPRIL Basic information

Product Name:
DELAPRIL
Synonyms:
  • [N-(Indan-2-yl)-N-[(S)-1-[(S)-3-phenyl-1-(ethoxycarbonyl)propylamino]ethylcarbonyl]amino]acetic acid
  • N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-Ala-N-(indan-2-yl)Gly-OH
  • Delaprilum
  • Delaprilum [latin]
  • Unii-W77ual9thi
  • N-[N-[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-N-(indan-2-yl)glycine
  • DELAPRIL
  • Alindapril
CAS:
83435-66-9
MF:
C26H32N2O5
MW:
452.54
Mol File:
83435-66-9.mol
More
Less

DELAPRIL Chemical Properties

Boiling point:
659.7±55.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O:0.005(Max Conc. mg/mL);0.01(Max Conc. mM)
pka
3.07±0.10(Predicted)
More
Less

DELAPRIL Usage And Synthesis

Chemical Properties

Delapril Hydrochloride: C26H32N2O5?HCl. [83435-67-0]. Obtained as colorless flaky crystals from acetone-hydrochloric acid, melting point 166-170°C (decomposition). [α]D22+18.5 (C=1, methanol).

Uses

Antihypertensive; enzyme inhibitor (angiotensinconverting).

Definition

ChEBI: Delapril is a peptide.

in vivo

Delapril (5-20 mg/kg, fed in drinking water) slows the progression of atherosclerosis in cholesterol-fed rabbits[2].
Delapril (1-10 mg/kg, p.o., daily for 5 weeks) shows antihypertensive effect spontaneously in hypertensive rats[3].

Animal Model:Cholesterol-fed rabbits[2]
Dosage:5 mg/kg at D5, 10 mg/kg at D10, 20 mg/kg at D20
Administration:Fed in a fixed volume (10 ml) of drinking water
Result:Decreased aortic area covered by lesions.
Restored endothelium-dependent relaxation

DELAPRIL Preparation Products And Raw materials

Raw materials

Magnesium sulfateEthyl chloroformateBROMOCHLORODIFLUOROMETHANE2-IndanoneN-Carbobenzyloxy-L-alaninetert-Butyl glycinate

DELAPRILSupplier

Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Email
waley188@sohu.com
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Wuhan Magic Biological Technology Co., Ltd.
Tel
18872289958、027-52304252、3400508168
Email
3400508168@qq.com
More
Less

DELAPRIL(83435-66-9)Related Product Information