4-CYANO-3-METHYLISOQUINOLINE Chemical Properties

Boiling point:

330.9±22.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DMSO (50mg/ml)

form 

solid

pka

2.26±0.31(Predicted)

color 

white

4-CYANO-3-METHYLISOQUINOLINE Usage And Synthesis

Uses

4-Cyano-3-methylisoquinoline is an inhibitor for protein kinase A (PKA) with an IC50 of micromolar level. 4-Cyano-3-methylisoquinoline reverses morphine tolerance in mouse model[1].

Definition

ChEBI: 3-methyl-4-isoquinolinecarbonitrile is a member of isoquinolines.

Biological Activity

Cell permeable: yes', 'Primary Target
PKA', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 30 nM against protein kinase A

storage

+4°C

References

[1] Smith FL, et al., The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA. Brain Res. 2003 Sep 19;985(1):78-88. DOI:10.1016/s0006-8993(03)03170-6

4-CYANO-3-METHYLISOQUINOLINE(161468-32-2)Related Product Information

• 7-Bromo-4-methylisoquinoline
• 1-METHYLISOQUINOLINE
• 6-Chloro-3-methylisoquinoline
• 5-methylisoquinoline
• 3-Chloro-4-methylisoquinoline
• 7-bromo-6-methylisoquinoline
• 6-Bromo-3-methylisoquinoline
• 4-Amino-1-methylisoquinoline
• 5-Bromo-4-methylisoquinoline
• 1-CHLORO-5-METHYLISOQUINOLINE
• 6-fluoro-8-methylisoquinoline
• 5-bromo-8-methylisoquinoline
• 5-amino-6-methylisoquinoline
• 6-AMino-4-Methylisoquinoline
• 8-bromo-3-methylisoquinoline
• 3-Chloro-7-Methylisoquinoline
• 1,3-dimethylisoquinoline
• 7-fluoro-3-methylisoquinoline