(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE Basic information
- Product Name:
- (2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
- Synonyms:
-
- NAS-181
- (2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
- NAS-181 methanesulfonate
- CAS:
- 205242-62-2
- MF:
- C20H30N2O7S
- MW:
- 442.53
- Product Categories:
-
- Serotonin receptor
- Mol File:
- 205242-62-2.mol
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(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE Chemical Properties
- storage temp.
- Desiccate at -20°C
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(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE Usage And Synthesis
Uses
NAS-181 is a SR-1B antagonist.
Biological Activity
Potent, selective antagonist at the rat 5-HT 1B receptor (K i = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo .
in vivo
NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions[1].
| Animal Model: | Rats[1] |
| Dosage: | 20 mg/kg |
| Administration: | S.c. |
| Result: | Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal?cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40?60%). |
(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATESupplier
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