BICALUTAMIDE-D4 Chemical Properties

Melting point:

192-1940C

Boiling point:

650.308±55.00 °C(Press: 760.00 Torr)(predicted)

Density 

1.522±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)

pka

11.492±0.29(predicted)

form 

Solid

color 

White to Off-White

BICALUTAMIDE-D4 Usage And Synthesis

Description

Bicalutamide-d₄ is intended for use as an internal standard for the quantification of bicalutamide by GC- or LC-MS. Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (K_i = 12.5 μM; IC₅₀ = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.

Chemical Properties

BICALUTAMIDE-D4 is White Solid

Uses

BICALUTAMIDE-D4 is used as an antiandrogen, antineoplastic (hormonal). (94%d4; 5.7%d3, 0.1%d1, no d0

References

[1] SN FREEMAN  BJA F  WIP Mainwaring. A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334)[J]. British Journal of Cancer, 1989, 60 5: 664-668. DOI: 10.1038/bjc.1989.336
[2] DAVID MASIELLO. Bicalutamide Functions as an Androgen Receptor Antagonist by Assembly of a Transcriptionally Inactive Receptor*[J]. The Journal of Biological Chemistry, 2002, 28 1: 26321-26326. DOI: 10.1074/jbc.m203310200
[3] WENQING GAO J T D Juhyun Kim. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands.[J]. Pharmaceutical Research, 2006, 23 8: 1641-1658. DOI: 10.1007/s11095-006-9024-3
[4] DONGHUA YIN. Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor.[J]. Molecular Pharmacology, 2003, 63 1: 211-223. DOI: 10.1124/mol.63.1.211

BICALUTAMIDE-D4(1185035-71-5)Related Product Information

• Desfluoro Bicalutamide
• 3-Fluoro-4-desfluoro BicalutaMide
• Deshydroxy Bicalutamide
• (S)-BICALUTAMIDE
• 3-(4-Fluobenzenesulfhydry)-2-hydroxyl-2-methylpropionic acid
• Bicalutamide
• Bicalutamide EP Impurity K
• N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
• (S)-6-Chloro-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-ol 1,1-dioxide
• N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(2-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
• (R)-Bicalutamide
• 3,4-Dihydro-2-(3-methoxypropyl)-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
• brinzolamide
• Brinzolamide
• Brinzolamide impurity
• Brinzolamide impurity
• BrinzolaMide IMpurity C
• (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide