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BICALUTAMIDE-D4

Product Name
BICALUTAMIDE-D4
CAS No.
1185035-71-5
Chemical Name
BICALUTAMIDE-D4
Synonyms
Casodex-d4;ICI-176334-d4;(CI-176334-D4;BICALUTAMIDE-D4;[2H4]-Bicalutamide;Bicalutamide Impurity 17;N-[4-Cyano-3-trifluoromethyl)phenyl]- 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide-d4;N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl-2,3,5,6-d4)sulfonyl)-2-hydroxy-2-methylpropanamide;Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-2,3,5,6-d4)sulfonyl]-2-hydroxy-2-methyl-
CBNumber
CB2737393
Molecular Formula
C18H10D4F4N2O4S
Formula Weight
434.4
MOL File
1185035-71-5.mol
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BICALUTAMIDE-D4 Property

Melting point:
192-1940C
Boiling point:
650.308±55.00 °C(Press: 760.00 Torr)(predicted)
Density 
1.522±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
pka
11.492±0.29(predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22377
Product name
Bicalutamide-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
500μg
Price
$219
Updated
2024/03/01
Cayman Chemical
Product number
22377
Product name
Bicalutamide-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
1mg
Price
$414
Updated
2024/03/01
Usbiological
Product number
B1087-55A
Product name
Bicalutamide-d4
Packaging
1mg
Price
$496
Updated
2021/12/16
TRC
Product number
B382002
Product name
Bicalutamide-d4
Packaging
10mg
Price
$1695
Updated
2021/12/16
AK Scientific
Product number
3488DH
Product name
Bicalutamide-d4
Packaging
1mg
Price
$559
Updated
2021/12/16
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BICALUTAMIDE-D4 Chemical Properties,Usage,Production

Description

Bicalutamide-d4 is intended for use as an internal standard for the quantification of bicalutamide by GC- or LC-MS. Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki = 12.5 μM; IC50 = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.

Chemical Properties

BICALUTAMIDE-D4 is White Solid

Uses

BICALUTAMIDE-D4 is used as an antiandrogen, antineoplastic (hormonal). (94%d4; 5.7%d3, 0.1%d1, no d0

References

[1] SN FREEMAN  BJA F  WIP Mainwaring. A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334)[J]. British Journal of Cancer, 1989, 60 5: 664-668. DOI: 10.1038/bjc.1989.336
[2] DAVID MASIELLO. Bicalutamide Functions as an Androgen Receptor Antagonist by Assembly of a Transcriptionally Inactive Receptor*[J]. The Journal of Biological Chemistry, 2002, 28 1: 26321-26326. DOI: 10.1074/jbc.m203310200
[3] WENQING GAO J T D Juhyun Kim. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands.[J]. Pharmaceutical Research, 2006, 23 8: 1641-1658. DOI: 10.1007/s11095-006-9024-3
[4] DONGHUA YIN. Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor.[J]. Molecular Pharmacology, 2003, 63 1: 211-223. DOI: 10.1124/mol.63.1.211

BICALUTAMIDE-D4 Preparation Products And Raw materials

Raw materials

Preparation Products

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BICALUTAMIDE-D4 Suppliers

Canada 3 CHINA 36 India 4 United States 4 Global 47
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
Advantage
55
Hubei Yangxin Medical Technology Co., Ltd.
Tel
15374522761
Fax
QQ:2853117752
Email
3003392093@yongstandards.com
Country
China
ProdList
10000
Advantage
55
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 19925672674
Fax
QQ 3008233717
Email
3008233746@qq.com
Country
China
ProdList
9883
Advantage
12
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Jinan blalong chemical co. LTD
Tel
2710913286@.com
Email
1513643261@qq.com
Country
China
ProdList
14246
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Manhag Testing Technology Co., Ltd
Tel
020-3846 2365 19110442770
Email
458677837@qq.com
Country
China
ProdList
7775
Advantage
58
Shanghai YuZn Pharm. Technology Co.,Ltd.
Tel
15921286451; 15921286451
Email
2010681527@qq.com
Country
China
ProdList
5182
Advantage
58

1185035-71-5, BICALUTAMIDE-D4Related Search:

Desfluoro Bicalutamide 3-Fluoro-4-desfluoro BicalutaMide Deshydroxy Bicalutamide (S)-BICALUTAMIDE 3-(4-Fluobenzenesulfhydry)-2-hydroxyl-2-methylpropionic acid Bicalutamide Bicalutamide EP Impurity K N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide (S)-6-Chloro-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-ol 1,1-dioxide N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(2-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide (R)-Bicalutamide 3,4-Dihydro-2-(3-methoxypropyl)-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide brinzolamide Brinzolamide Brinzolamide impurity Brinzolamide impurity BrinzolaMide IMpurity C (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

  • BICALUTAMIDE-D4
  • Casodex-d4
  • ICI-176334-d4
  • N-[4-Cyano-3-trifluoromethyl)phenyl]- 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide-d4
  • (CI-176334-D4
  • Bicalutamide Impurity 17
  • [2H4]-Bicalutamide
  • Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-2,3,5,6-d4)sulfonyl]-2-hydroxy-2-methyl-
  • N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl-2,3,5,6-d4)sulfonyl)-2-hydroxy-2-methylpropanamide
  • 1185035-71-5
  • C18H10D4F4N2O4S
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Isotope Labelled Compounds