ChemicalBook > CAS DataBase List > BICALUTAMIDE-D4

BICALUTAMIDE-D4

Product Name
BICALUTAMIDE-D4
CAS No.
1185035-71-5
Chemical Name
BICALUTAMIDE-D4
Synonyms
Casodex-d4;ICI-176334-d4;(CI-176334-D4;BICALUTAMIDE-D4;[2H4]-Bicalutamide;Bicalutamide Impurity 17;N-[4-Cyano-3-trifluoromethyl)phenyl]- 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide-d4;N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl-2,3,5,6-d4)sulfonyl)-2-hydroxy-2-methylpropanamide;Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-2,3,5,6-d4)sulfonyl]-2-hydroxy-2-methyl-
CBNumber
CB2737393
Molecular Formula
C18H10D4F4N2O4S
Formula Weight
434.4
MOL File
1185035-71-5.mol
More
Less

BICALUTAMIDE-D4 Property

Melting point:
192-1940C
Boiling point:
650.308±55.00 °C(Press: 760.00 Torr)(predicted)
Density 
1.522±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
pka
11.492±0.29(predicted)
form 
Solid
color 
White to Off-White
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
22377
Product name
Bicalutamide-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
500μg
Price
$219
Updated
2024/03/01
Cayman Chemical
Product number
22377
Product name
Bicalutamide-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
1mg
Price
$414
Updated
2024/03/01
Usbiological
Product number
B1087-55A
Product name
Bicalutamide-d4
Packaging
1mg
Price
$496
Updated
2021/12/16
TRC
Product number
B382002
Product name
Bicalutamide-d4
Packaging
10mg
Price
$1695
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0007231
Product name
BICALUTAMIDE-D4
Purity
95.00%
Packaging
10MG
Price
$2194.5
Updated
2021/12/16
More
Less

BICALUTAMIDE-D4 Chemical Properties,Usage,Production

Description

Bicalutamide-d4 is intended for use as an internal standard for the quantification of bicalutamide by GC- or LC-MS. Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki = 12.5 μM; IC50 = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.

Chemical Properties

BICALUTAMIDE-D4 is White Solid

Uses

BICALUTAMIDE-D4 is used as an antiandrogen, antineoplastic (hormonal). (94%d4; 5.7%d3, 0.1%d1, no d0

References

[1] SN FREEMAN  BJA F  WIP Mainwaring. A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334)[J]. British Journal of Cancer, 1989, 60 5: 664-668. DOI: 10.1038/bjc.1989.336
[2] DAVID MASIELLO. Bicalutamide Functions as an Androgen Receptor Antagonist by Assembly of a Transcriptionally Inactive Receptor*[J]. The Journal of Biological Chemistry, 2002, 28 1: 26321-26326. DOI: 10.1074/jbc.m203310200
[3] WENQING GAO J T D Juhyun Kim. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands.[J]. Pharmaceutical Research, 2006, 23 8: 1641-1658. DOI: 10.1007/s11095-006-9024-3
[4] DONGHUA YIN. Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor.[J]. Molecular Pharmacology, 2003, 63 1: 211-223. DOI: 10.1124/mol.63.1.211

BICALUTAMIDE-D4 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BICALUTAMIDE-D4 Suppliers

Canada 3 CHINA 35 India 4 United States 4 Global 46
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
TLC PharmaChem Inc.
Tel
--
Fax
--
Email
research@tlcpharmachem.com
Country
Canada
ProdList
921
Advantage
60
SynFine Research, Inc.
Tel
--
Fax
--
Email
research@synfine.com.
Country
Canada
ProdList
768
Advantage
42

1185035-71-5, BICALUTAMIDE-D4Related Search:

Desfluoro Bicalutamide 3-Fluoro-4-desfluoro BicalutaMide Deshydroxy Bicalutamide (S)-BICALUTAMIDE 3-(4-Fluobenzenesulfhydry)-2-hydroxyl-2-methylpropionic acid Bicalutamide Bicalutamide EP Impurity K N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide (S)-6-Chloro-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-ol 1,1-dioxide N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(2-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide (R)-Bicalutamide 3,4-Dihydro-2-(3-methoxypropyl)-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide brinzolamide Brinzolamide Brinzolamide impurity Brinzolamide impurity BrinzolaMide IMpurity C (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

  • BICALUTAMIDE-D4
  • Casodex-d4
  • ICI-176334-d4
  • N-[4-Cyano-3-trifluoromethyl)phenyl]- 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide-d4
  • (CI-176334-D4
  • Bicalutamide Impurity 17
  • [2H4]-Bicalutamide
  • Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-2,3,5,6-d4)sulfonyl]-2-hydroxy-2-methyl-
  • N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl-2,3,5,6-d4)sulfonyl)-2-hydroxy-2-methylpropanamide
  • 1185035-71-5
  • C18H10D4F4N2O4S
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Isotope Labelled Compounds