N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide

Product Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
CAS No.: 90356-78-8
Chemical Name: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
Synonyms: BicalutaMide Sulfide;Bicalutamide-EP-Imp-J;Bicalutamide Impurity J;Bicalutamide Intermediate;Bicalutamide EP Impurity J;INTERMEDIATE OF BICALUTAMIDE;N-[4-Cyano-3-(trifluoromethyl);Bicalutamide Impurity 8(EP Impurity J);Bicalutamide intermediate (thio ether);BICALUTAMIDE-SULFIDE (BICALUTAMIDE ASH)
CBNumber: CB8250746
Molecular Formula: C18H14F4N2O2S
Formula Weight: 398.37
MOL File: 90356-78-8.mol

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N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Property

Melting point:: 109-111°C
Boiling point:: 565.6±50.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 12.31±0.29(Predicted)
color: White
PH: 6.45 at 24℃ and 10g/L
InChI: InChI=1S/C18H14F4N2O2S/c1-17(26,10-27-14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChIKey: GCGWWKKSGPETMI-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)(=O)C(O)(C)CSC1=CC=C(F)C=C1
LogP: 3.8 at 30℃
CAS DataBase Reference: 90356-78-8(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B382040
Product name: BicalutamideSulfide
Packaging: 250mg
Price: $120
Updated: 2021/12/16

TRC

Product number: B382040
Product name: BicalutamideSulfide
Packaging: 1g
Price: $365
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IB18585
Product name: Bicalutamide sulfide
Packaging: 5G
Price: $450
Updated: 2021/12/16

Matrix Scientific

Product number: 090739
Product name: N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((4-fluoro-phenyl)thio)-2-hydroxy-2-methylpropanamide
Purity: 95+%
Packaging: 250mg
Price: $681
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0002253
Product name: N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO]-2-HYDROXY-2-METHYLPROPIONAMIDE
Purity: 95.00%
Packaging: 250MG
Price: $716.1
Updated: 2021/12/16

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N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Bicalutamide intermediate.

Synthesis

371-42-6

90357-51-0

90356-78-8

Example 1 Preparation of N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropanamide: 4-Fluorobenzenethiol (21 g) was dissolved in methanol (65 ml) and cooled to 0°C. 50% aqueous sodium hydroxide solution (14g) was added in batches under stirring. The reaction mixture was stirred at 0°C for 30 min, followed by continued stirring at 25°C for 1 hr. N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyl oxirane amide (40 g) was added to the reaction system and the reaction was stirred at room temperature for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, water (100 ml) was added to the mixture and the pH was adjusted to below 7 with concentrated hydrochloric acid. Methanol was removed by distillation under reduced pressure until no methanol was distilled. The resulting suspension was stirred at 5°C for 3 h. The solid product was collected by filtration and washed with water (2 x 40 ml). Finally, the solid was dried under vacuum at 50-60°C to afford the target product N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropanamide 58 g in 98% yield.

References

[1] Patent: US2007/27211, 2007, A1. Location in patent: Page/Page column 2; 4
[2] Patent: US2003/191337, 2003, A1. Location in patent: Page/Page column 5; 11
[3] Patent: US2013/274501, 2013, A1. Location in patent: Paragraph 0107; 0108; 0109
[4] Patent: US2003/191337, 2003, A1. Location in patent: Page/Page column 5; 11
[5] Patent: US2003/191337, 2003, A1. Location in patent: Page/Page column 12; 13

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide Suppliers

Canada 1 China 175 Europe 2 Germany 1 India 18 Spain 1 Ukraine 1 United Kingdom 6 United States 20 Global 225

Jiangxi Jinfeng Pharmaceutical Co., Ltd

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Shanghai Longsheng chemical Co.,Ltd.

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Chemsky（shanghai）International Co.,Ltd.

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View Lastest Price from N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide 90356-78-8
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-29

Career Henan Chemical Co

Product: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide 90356-78-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: as request
Release date: 2018-12-23

90356-78-8, N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamideRelated Search:

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Bicalutamide EP Impurity J

N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropiomide

4-CYANO-3-TRIFLUOROMETHYL-N-[3-(4-FLUOROPHENYLTHIO)-2-HYDROXYL-2-METHYLPROPIONYL]ANILINE

(S)-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-(4-FLUOROPHENYLTHIO)-2-HYDROXY-2-METHYLPROPANAMIDE

N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO]-2-HYDROXY-2-METHYL PROPANAMIDE

N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO]-2-HYDROXY-2-METHYLPROPIONAMIDE

Bicalutamide Intermediate

BICALUTAMIDE-SULFIDE (BICALUTAMIDE ASH)

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N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)THIO] -2- HYDROXY-2-MET

4-OYANO-3-TRIFLUOROMETHYL-N-[3-(4-FLUOROPHENYLTHIO)-2-HYDROXYL-2-METHYLPROPIONYL]ANILINE

H-(4-CYANO-3-TRIFLUOROMTHYLPHENYL)-3-(4-FLOUROPHENYLSULFANYL)-2-HYDROXY-2-METHYLPROPIONAMIDE

N-[4-cyano-3-(rifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-

N-[4-Cyano-3-(trifluoromethyl)

4-cyano-3-trifluoromethyl-N-[3-(4-fluorophenylthio)-2-hydroxyl-2-methylpropionyl]aniline (intermediate of bicalutamide)

INTERMEDIATE OF BICALUTAMIDE

4-Cyano-3-(trifluoromethyl)phenyl-3-(4-fluorophenyl)thio)-2-methylpropanamide

BicalutaMide Sulfide

(2S)-N-[4-cyano-3-(trifluoroMethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-MethylpropanaMide

N-[4-Cyano-3-trifluoromethy phenyl]-S-(4-fluorophenylthio)-2-hydrdoxy-2-methyl-propionamide

Bicalutamide Impurity 8(EP Impurity J)

Bicalutamide-EP-Imp-J

N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Thio]-2-Hydroxy-2-Methylpropionamid

Bicalutamide EP Impurity J (Bicalutamide Sulfide)

N-[4-Cyano-3-(Trifluoromethyl)phenyl]-3-[(4-Fluorophenyl)thio]-2-Hydroxy-2-Methyl

Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl-

Bicalutamide Impurity 8(Bicalutamide EP Impurity J)

N-[4-cyano-3-tri?uoromethylphenyl]-3-[4-?uorophenylthio]-2- hydroxy-2methylpropionamide

N-[4-Cyano-3-(Trifluoromethyl)phenyl]-3-[(4-Fluorophenyl)thi...

3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamideQ: What is 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Q: What is the CAS Number of 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Q: What is the storage condition of 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide Q: What are the applications of 3-(4-fluorophenylthio)-N-(4-Cyano-3-(trifluoromethyl) phenyl)-2-hydroxy-2-methylpropanamide

Bicalutamide intermediate (thio ether) N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide

Bicalutamide Impurity J

N - [4-Cyano-3- (trifluoromethyl) phenyl] -3- (4-fluorophenylthiol) -2-hydroxy-2-methylpropanamide

4-Cyano-3-trifluoromethyl-N-[3-(4-fluorophenyl)thio-2-hydroxy-2-methylpropionyl]aniline

Bicalutamide intermediate (thio ether)

N-[4-Cyano-3- (trifluoromethyl)phenyl]-3- [(4-fluorophenyl)thio]-2-

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

(2RS)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanami

(2RS)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

90356-78-8

90326-78-8

C18H14F4N2O2S

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Bicalutamide

(intermediate of bicalutamide)