ChemicalBook > CAS DataBase List > BICALUTAMIDE-D4

BICALUTAMIDE-D4

Product Name: BICALUTAMIDE-D4
CAS No.: 1185035-71-5
Chemical Name: BICALUTAMIDE-D4
Synonyms: Casodex-d4;ICI-176334-d4;(CI-176334-D4;BICALUTAMIDE-D4;[2H4]-Bicalutamide;Bicalutamide Impurity 17;N-[4-Cyano-3-trifluoromethyl)phenyl]- 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide-d4;N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl-2,3,5,6-d4)sulfonyl)-2-hydroxy-2-methylpropanamide;Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-2,3,5,6-d4)sulfonyl]-2-hydroxy-2-methyl-
CBNumber: CB2737393
Molecular Formula: C18H10D4F4N2O4S
Formula Weight: 434.4
MOL File: 1185035-71-5.mol

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BICALUTAMIDE-D4 Property

Melting point:: 192-1940C
Boiling point:: 650.308±55.00 °C(Press: 760.00 Torr)(predicted)
Density: 1.522±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
pka: 11.492±0.29(predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22377
Product name: Bicalutamide-d4
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 500μg
Price: $219
Updated: 2024/03/01

Cayman Chemical

Product number: 22377
Product name: Bicalutamide-d4
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 1mg
Price: $414
Updated: 2024/03/01

Usbiological

Product number: B1087-55A
Product name: Bicalutamide-d4
Packaging: 1mg
Price: $496
Updated: 2021/12/16

TRC

Product number: B382002
Product name: Bicalutamide-d4
Packaging: 10mg
Price: $1695
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0007231
Product name: BICALUTAMIDE-D4
Purity: 95.00%
Packaging: 10MG
Price: $2194.5
Updated: 2021/12/16

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BICALUTAMIDE-D4 Chemical Properties,Usage,Production

Description

Bicalutamide-d₄ is intended for use as an internal standard for the quantification of bicalutamide by GC- or LC-MS. Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (K_i = 12.5 μM; IC₅₀ = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.

Chemical Properties

BICALUTAMIDE-D4 is White Solid

Uses

BICALUTAMIDE-D4 is used as an antiandrogen, antineoplastic (hormonal). (94%d4; 5.7%d3, 0.1%d1, no d0

References

[1] SN FREEMAN BJA F WIP Mainwaring. A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334)[J]. British Journal of Cancer, 1989, 60 5: 664-668. DOI: 10.1038/bjc.1989.336
[2] DAVID MASIELLO. Bicalutamide Functions as an Androgen Receptor Antagonist by Assembly of a Transcriptionally Inactive Receptor*[J]. The Journal of Biological Chemistry, 2002, 28 1: 26321-26326. DOI: 10.1074/jbc.m203310200
[3] WENQING GAO J T D Juhyun Kim. Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands.[J]. Pharmaceutical Research, 2006, 23 8: 1641-1658. DOI: 10.1007/s11095-006-9024-3
[4] DONGHUA YIN. Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor.[J]. Molecular Pharmacology, 2003, 63 1: 211-223. DOI: 10.1124/mol.63.1.211

BICALUTAMIDE-D4 Preparation Products And Raw materials

Raw materials

Preparation Products

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1185035-71-5, BICALUTAMIDE-D4Related Search:

Desfluoro Bicalutamide 3-Fluoro-4-desfluoro BicalutaMide Deshydroxy Bicalutamide (S)-BICALUTAMIDE 3-(4-Fluobenzenesulfhydry)-2-hydroxyl-2-methylpropionic acid Bicalutamide Bicalutamide EP Impurity K N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide (S)-6-Chloro-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-4-ol 1,1-dioxide N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(2-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide (R)-Bicalutamide 3,4-Dihydro-2-(3-methoxypropyl)-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide brinzolamide Brinzolamide Brinzolamide impurity Brinzolamide impurity BrinzolaMide IMpurity C (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

BICALUTAMIDE-D4

Casodex-d4

ICI-176334-d4

N-[4-Cyano-3-trifluoromethyl)phenyl]- 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide-d4

(CI-176334-D4

Bicalutamide Impurity 17

[2H4]-Bicalutamide

Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-2,3,5,6-d4)sulfonyl]-2-hydroxy-2-methyl-

N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl-2,3,5,6-d4)sulfonyl)-2-hydroxy-2-methylpropanamide

1185035-71-5

C18H10D4F4N2O4S

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Pharmaceuticals

Sulfur & Selenium Compounds

Isotope Labelled Compounds