1,3-DIMETHYL-1H-PYRAZOLE-5-CARBALDEHYDE Chemical Properties

Melting point:

40-42°C

Boiling point:

80-83 °C(Press: 12 Torr)

Density 

1.11±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

1.03±0.10(Predicted)

form 

solid

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

25016-09-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

HazardClass 

IRRITANT

HS Code 

29331990

1,3-DIMETHYL-1H-PYRAZOLE-5-CARBALDEHYDE Usage And Synthesis

Chemical Properties

Colorless to light yellow liquid

Synthesis

Step 2: Preparation of 2,5-dimethyl-2H-pyrazole-3-carbaldehyde (15) A mixture of compound 14 (1,3-dimethyl-5-hydroxymethyl-1H-pyrazole, 3 g, 23.8 mmol) with pyridinium dichromate (13.4 g, 35.7 mmol) in dichloromethane (100 ml) was reacted for 16 hrs at 25°C under nitrogen protection with stirring. After completion of the reaction, the reaction mixture was filtered and the filtrate was collected. The filtrate was dried over anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography to afford the target product 2,5-dimethyl-2H-pyrazole-3-carbaldehyde (15) as a 1 g brown solid in 34% yield. Product characterization data: 1H NMR (200 MHz, CDCl3): δ 9.8 (s, 1H), 6.6 (s, 1H), 4.1 (s, 3H), 2.3 (s, 3H). Mass spectrum (CI method, isobutane): 125 (M + 1, 100%). IR spectrum (KBr, cm-1): νmax 1688.

References

[1] Patent: US2006/128729, 2006, A1. Location in patent: Page/Page column 98
[2] Patent: WO2005/9941, 2005, A1. Location in patent: Page 45-46
[3] Patent: WO2009/101082, 2009, A1. Location in patent: Page/Page column 71

1,3-DIMETHYL-1H-PYRAZOLE-5-CARBALDEHYDE(25016-09-5)Related Product Information

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