5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde Chemical Properties

Melting point:

78-79°C

Boiling point:

255.7±35.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

pka

-0.60±0.10(Predicted)

color 

White to Yellow to Orange

CAS DataBase Reference

27006-76-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-37/39-36/37/39-22

RIDADR 

2811

HazardClass 

IRRITANT

HS Code 

29124990

MSDS

• Language:English Provider:ALFA

5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde Usage And Synthesis

Chemical Properties

Off-white to brown solid

Synthesis

Step 2: Synthesis of 5-chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde: 2,5-dimethyl-1H-pyrazol-3(2H)-one (32 g, 285.71 mmol) was mixed with POCl3 (128 mL) at 0 °C and N,N-dimethylformamide (26.35 mL, 342.85 mmol) was added slowly. The reaction mixture was warmed to 100 °C and stirred for 7 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was alkalized with aqueous sodium bicarbonate and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography to afford the target compound 5-chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde (28 g, 62.0% yield).

References

[1] Patent: WO2015/10049, 2015, A1. Location in patent: Paragraph 0712; 0713
[2] Patent: WO2015/200650, 2015, A1. Location in patent: Paragraph 0519; 0522-0523
[3] Patent: CN103951663, 2016, B. Location in patent: Paragraph 0221; 0224; 0225

5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde(27006-76-4)Related Product Information

• Pyrazole
• Dimethyl fumarate
• Dimethyl ether
• N,N-Dimethylformamide
• Dimethyl sulfoxide
• Pyraclostrobin
• 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
• Dimethyl sulfide
• Zolpidem tartrate
• Dimethyl phthalate
• ETHANE
• Zolpidem
• 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
• 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXALDEHYDE
• 5-CHLORO-1,3-DIMETHYLPYRAZOLE
• 1H-Pyrazole-4-carboxaldehyde
• 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde